ArticleProceedings of the National Academy of Sciences of the United States of America2006
Selection and analysis of spontaneous reciprocal mitotic cross-overs in Saccharomyces cerevisiae.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
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Who cites it
55 citing papers in PubMed.
- Lesions initiating spontaneous mitotic crossover are minimally subject to non-homologous end joining.bioRxiv : the preprint server for biology · 2026Article
- Spontaneous and environment induced genomic alterations in yeast model.Cell insight · 2025Review
- The dynamics of loss of heterozygosity events in genomes.EMBO reports · 2025Review
- Overdominant Mutations Restrict Adaptive Loss of Heterozygosity at Linked Loci.Genome biology and evolution · 2021Article
- Mitotic gene conversion can be as important as meiotic conversion in driving genetic variability in plants and other species without early germline segregation.PLoS biology · 2021Article
- Therapeutic Dose of Hydroxyurea-Induced Synaptic Abnormalities on the Mouse Spermatocyte.Frontiers in physiology · 2021Article
- Recombination and Pol ζ Rescue Defective DNA Replication upon Impaired CMG Helicase-Pol ε Interaction.International journal of molecular sciences · 2020Article
- Article
- Review
- Guidelines for DNA recombination and repair studies: Cellular assays of DNA repair pathways.Microbial cell (Graz, Austria) · 2019Review
- GC content elevates mutation and recombination rates in the yeastProceedings of the National Academy of Sciences of the United States of America · 2018Article
- Genetic Control of Genomic Alterations Induced in Yeast by Interstitial Telomeric Sequences.Genetics · 2018Article
- Genome Dynamics of HybridG3 (Bethesda, Md.) · 2017Article
- Clonal Heterogeneity Influences the Fate of New Adaptive Mutations.Cell reports · 2017Article
- Article
- Pathways and Mechanisms that Prevent Genome Instability inGenetics · 2017Review
- Remarkably Long-Tract Gene Conversion Induced by Fragile Site Instability in Saccharomyces cerevisiae.Genetics · 2016Article
- High-Resolution Mapping of Homologous Recombination Events in rad3 Hyper-Recombination Mutants in Yeast.PLoS genetics · 2016Article
- Article
- Genome-destabilizing effects associated with top1 loss or accumulation of top1 cleavage complexes in yeast.PLoS genetics · 2015Article
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2 authors.
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Abstract
We developed a system that allows the selection of the reciprocal products resulting from spontaneous mitotic cross-overs in the yeast Saccharomyces cerevisiae. A number of other types of genetic events, including chromosome loss, can be monitored with this system. For a 120-kb chromosome interval on chromosome V (CEN5-CAN1), the rate of mitotic cross-overs was 4x10(-5) per division, a rate approximately 25,000-fold lower than the meiotic rate of cross-overs. We found no suppression of mitotic cross-overs near the centromere of chromosome V, unlike the suppression observed for meiotic exchanges. The rate of reciprocal cross-overs was substantially (38-fold) elevated by treatment of cells with hydroxyurea, a drug that reduces nucleotide pools and slows DNA replication.
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