SynthesisAJNR. American journal of neuroradiology2006
A systematic literature review of magnetic resonance spectroscopy for the characterization of brain tumors.
Synthesis in AJNR. American journal of neuroradiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
58 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The diagnostic performance of magnetic resonance spectroscopy in differentiating high-from low-grade gliomas: A systematic review and meta-analysis.European radiology · 2016Pooled it
- The role of imaging in the management of progressive glioblastoma : a systematic review and evidence-based clinical practice guideline.Journal of neuro-oncology · 2014Guideline
- Characterization of intracranial space-occupying lesions by ⁹⁹(m)Tc-Tetrofosmin SPECT.Journal of neuro-oncology · 2011Trial
- Pituitary enlargement and hypopituitarism in patient with lung cancer treated with immune checkpoint inhibitors: Metastasis or hypophysitis? Role of imaging.Radiology case reports · 2025Article
- Article
- The role of 3-Tesla magnetic resonance perfusion and spectroscopy in distinguishing glioblastoma from solitary brain metastasis.Journal of clinical imaging science · 2023Article
- Revisiting the use of proton magnetic resonance spectroscopy in distinguishing between primary and secondary malignant tumors of the central nervous system.The neuroradiology journal · 2022Article
- Glioblastoma in Patients With Multiple Sclerosis.The Neurohospitalist · 2022Article
- 82Rubidium chloride positron emission tomography discrimination of recurrent intracranial malignancy from radiation necrosis.The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of... · 2022Article
- Deuterium Metabolic Imaging of the Healthy and Diseased Brain.Neuroscience · 2021Review
- 31-Phosphorus Magnetic Resonance Spectroscopy in Evaluation of Glioma and Metastases in 3T MRI.The Indian journal of radiology & imaging · 2021Article
- Systematic Review of the Neural Effect of Electroconvulsive Therapy in Patients with Schizophrenia: Hippocampus and Insula as the Key Regions of Modulation.Psychiatry investigation · 2021Article
- Analyzing magnetic resonance imaging data from glioma patients using deep learning.Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society · 2021Review
- Diagnostic accuracy and added value of qualitative radiological review ofNeuro-oncology practice · 2019Article
- Oligodendroglioma confers higher risk of radiation necrosis.Journal of neuro-oncology · 2019Article
- The Role of Magnetic Resonance Spectroscopy in Evaluating the Rate of Brain Metabolic Variations in Chemical Veterans with Respiratory Problem In Comparison To Control Group.Open access Macedonian journal of medical sciences · 2018Article
- MultivoxelTomography (Ann Arbor, Mich.) · 2018Article
- Prospective multicentre evaluation and refinement of an analysis tool for magnetic resonance spectroscopy of childhood cerebellar tumours.Pediatric radiology · 2018Article
- Evaluation of the added value ofNeuro-oncology practice · 2018Article
- Brain Radiation Necrosis: Current Management With a Focus on Non-small Cell Lung Cancer Patients.Frontiers in oncology · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeProton MR spectroscopy ((1)H-MR spectroscopy) is a potentially useful adjunct to anatomic MR imaging in the characterization of brain tumors. We performed an updated systematic review of the evidence.
methodsWe employed a standardized search strategy to find studies published during 2002-2004. We reviewed studies measuring diagnostic accuracy and diagnostic, therapeutic, or health impact of (1)H-MR spectroscopy. We abstracted information on study design, (1)H-MR spectroscopy technique, and methodologic quality. We categorized studies into 5 subgroups: (1) metastasis versus high-grade tumor; (2) high-versus low-grade tumor; (3) recurrent tumor versus radiation necrosis; (4) tumor extent; and (5) tumor versus non-neoplastic lesion.
resultsWe identified 26 studies evaluating diagnostic performance, diagnostic impact, or therapeutic impact. No articles evaluated patient health or cost-effectiveness. Methodologic quality was mixed; most used histopathology as the reference standard but did not specify blinded interpretation of histopathology. One large study demonstrated a statistically significant increase in diagnostic accuracy for indeterminate brain lesions from 55%, based on MR imaging, to 71% after analysis of (1)H-MR spectroscopy. Several studies have found that (1)H-MR spectroscopy is highly accurate for distinguishing high- and low-grade gliomas, though the incremental benefit of (1)H-MR spectroscopy in this setting is less clear. Interpretation for the other clinical subgroups is limited by the small number of studies.
conclusionThe current evidence on the accuracy of (1)H-MR spectroscopy in the characterization of brain tumors is promising. However, additional high-quality studies are needed to convince policy makers. We present guidelines to help focus future research in this area.
Indexed as
Identifiers
16908548PMC7977543What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.