ArticleClinical and experimental immunology2006
Mannan-binding lectin plasma levels in leprosy: deficiency confers protection against the lepromatous but not the tuberculoid forms.
Article in Clinical and experimental immunology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 80 citations in OpenAlex.
- Association ofFrontiers in immunology · 2021Pooled it
- Mannose-binding lectin and susceptibility to tuberculosis: a meta-analysis.Clinical and experimental immunology · 2010Pooled it
- Leprosy: treatment, prevention, immune response and gene function.Frontiers in immunology · 2024Review
- Adding MASP1 to the lectin pathway-Leprosy association puzzle: Hints from gene polymorphisms and protein levels.PLoS neglected tropical diseases · 2020Article
- Hepatitis B Virus Infection Among Leprosy Patients: A Case for Polymorphisms Compromising Activation of the Lectin Pathway and Complement Receptors.Frontiers in immunology · 2020Article
- Association ofFrontiers in immunology · 2020Article
- Complement receptor 1 (CR1, CD35) association with susceptibility to leprosy.PLoS neglected tropical diseases · 2018Article
- Protein profile of leprosy patients with plantar ulcers from the Eastern Amazon region.Infectious diseases of poverty · 2017Article
- Association of mannose-binding lectin gene polymorphisms with the development of pulmonary tuberculosis in China.BMC infectious diseases · 2017Article
- Association of a new FCN3 haplotype with high ficolin-3 levels in leprosy.PLoS neglected tropical diseases · 2017Article
- MBL-associated serine proteases (MASPs) and infectious diseases.Molecular immunology · 2015Review
- The lectin pathway of complement and rheumatic heart disease.Frontiers in pediatrics · 2014Review
- Genetic variants of complement genes ficolin-2, mannose-binding lectin and complement factor H are associated with leprosy in Han Chinese from Southwest China.Human genetics · 2013Article
- Susceptibility to leprosy is associated with M-ficolin polymorphisms.Journal of clinical immunology · 2013Article
- The investigation of allele and genotype frequencies of human C3 (rs2230199) in south Iranian population.Molecular biology reports · 2012Article
- Human polymorphisms as clinical predictors in leprosy.Journal of tropical medicine · 2011Article
- Leprosy and the human genome.Microbiology and molecular biology reviews : MMBR · 2010Review
- Association of TNF, MBL, and VDR polymorphisms with leprosy phenotypes.Human immunology · 2010Article
- Common polymorphisms in the NOD2 gene region are associated with leprosy and its reactive states.The Journal of infectious diseases · 2010Article
- Mannan-binding lectin levels related to spontaneous abortion in Brazilian patients with celiac disease.Digestive diseases and sciences · 2008Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mannan-binding lectin (MBL) is an important component of the first-line defence against infections. Evidence has shown that MBL deficiency, reducing phagocytosis and internalization of intracellular pathogens may protect the host against intracellular infections such as leprosy. In this study, we speculated whether genetically determined low MBL serum levels confer protection against Mycobacterium leprae infection. One hundred and ninety-one patients with leprosy, presenting lepromatous (n = 118), tuberculoid (n = 31), dimorph (n = 30) and indeterminate (n = 12) clinical forms and 110 healthy controls matched with the patients according to sex, age and ethnic background were investigated. MBL concentrations were measured in a double-antibody enzyme immune assay and C-reactive protein (CRP) serum levels by nephelometry. A significant negative association of MBL low values (< 100 ng/ml) was observed with lepromatous patients when comparing with controls and tuberculoid patients [10/118, 8.47%versus 21/110, 19.09%P = 0.03 chi(2) with Yates' correction, odds ratio (OR) 0.39, confidence interval (CI) 0.18-0.88 and 8/31, 25.81%, P = 0.02, OR 0.27, CI 0.09-0.75, respectively]. There was no significant difference in the distribution of MBL levels between patients and controls or among the clinical forms. The concentration of CRP was significantly increased in the patients (P = 0.0002) and in the lepromatous form (P = 0.0001) when compared to controls. A weak positive correlation between MBL and CRP levels was observed in the patients (P = 0.010, R = 0.255). These data suggest a protective role for MBL deficiency against the development of the most severe and multi-bacillary form of leprosy.
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