ArticleInsect molecular biology2006
A novel association between clustered NF-kappaB and C/EBP binding sites is required for immune regulation of mosquito Defensin genes.
Article in Insect molecular biology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 25 citations in OpenAlex.
- Malaria mosquito antimicrobial defence requires immunity and detoxification gene regulation by Lola.Insect molecular biology · 2026Article
- Article
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- The effect of bacterial challenge on ferritin regulation in the yellow fever mosquito, Aedes aegypti.Insect science · 2013Article
- The effects of ingested mammalian blood factors on vector arthropod immunity and physiology.Microbes and infection · 2013Review
- Ingested human insulin inhibits the mosquito NF-κB-dependent immune response to Plasmodium falciparum.Infection and immunity · 2012Article
- The mitogen-activated protein kinome from Anopheles gambiae: identification, phylogeny and functional characterization of the ERK, JNK and p38 MAP kinases.BMC genomics · 2011Article
- Validation of novel promoter sequences derived from two endogenous ubiquitin genes in transgenic Aedes aegypti.Insect molecular biology · 2010Article
- Comparative genomics allows the discovery of cis-regulatory elements in mosquitoes.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Semliki Forest virus strongly reduces mosquito host defence signaling.Insect molecular biology · 2008Article
- The malaria vector mosquito Anopheles gambiae expresses a suite of larval-specific defensin genes.Insect molecular biology · 2008Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
A comparative analysis identified key cis-acting regulatory elements responsible for the temporal control of mosquito Defensin gene expression. The promoters of Anopheles gambiae Defensin 1 and two isoforms of Aedes aegypti Defensin A are up-regulated by immune challenge. This stimulated activity depends upon a cluster of three NF-kappaB binding sites and closely associated C/EBP-like motifs, which function as a unit for optimal promoter activity. Binding of NF-kappaB and C/EBP like transcription factors is confirmed by electrophoretic mobility shift assay, including supershifts with antibodies to C/EBP. KappaB-like motifs are abundant within antimicrobial peptide gene promoters and most are very closely associated with putative C/EBP binding sites. This novel association between NF-kappaB and C/EBP binding sites may, therefore, be of widespread significance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.