Trial reportGut2006
A randomised controlled trial of ablation of Barrett's oesophagus with multipolar electrocoagulation versus argon plasma coagulation in combination with acid suppression: long term results.
Trial report in Gut, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 5 syntheses or guidelines pooled it, 117 citations in OpenAlex.
- Efficacy and Safety of Argon Plasma Coagulation for the Ablation of Barrett's Esophagus: A Systemic Review and Meta-Analysis.Gut and liver · 2024Pooled it
- Guidelines for surgical treatment of gastroesophageal reflux disease.Surgical endoscopy · 2010Guideline
- Endoscopic treatments for Barrett's esophagus: a systematic review of safety and effectiveness compared to esophagectomy.BMC gastroenterology · 2010Pooled it
- Treatment for Barrett's oesophagus.The Cochrane database of systematic reviews · 2010Pooled it
- A systematic review and meta-analysis of the treatment for Barrett's esophagus.Digestive diseases and sciences · 2008Pooled it
- Safety, tolerability, and efficacy of endoscopic low-pressure liquid nitrogen spray cryotherapy in the esophagus.Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus · 2010Trial
- Prospective randomized trial of argon plasma coagulation ablation versus endoscopic surveillance of Barrett's esophagus in patients treated with antisecretory medication.Digestive diseases and sciences · 2009Trial
- Efficacy and Safety of Focal and Multifocal Cryoballoon Ablation for Barrett's Esophagus: A Systematic Review and Meta-analysis.Endoscopy international open · 2026Review
- Article
- Management of Dysplastic Barrett's Esophagus and Early Esophageal Adenocarcinoma.Gastroenterology clinics of North America · 2022Review
- How I Treat Patients With Barrett Esophagus When Endoscopic Ablation Fails.Gastroenterology & hepatology · 2020Article
- Review
- Ablation Therapy for Barrett's Esophagus: New Rules for Changing Times.Current gastroenterology reports · 2017Review
- Role of endoscopy in early oesophageal cancer.Nature reviews. Gastroenterology & hepatology · 2016Review
- Endoscopic ablation is a cost-effective cancer preventative therapy in patients with Barrett's esophagus who have elevated genomic instability.Endoscopy international open · 2016Article
- Long-term results of the mucosal ablation of Barrett's esophagus: efficacy and recurrence.Endoscopy international open · 2015Article
- Sixteen-year follow-up of Barrett's esophagus, endoscopically treated with argon plasma coagulation.United European gastroenterology journal · 2014Article
- Endoscopic assessment and management of early esophageal adenocarcinoma.World journal of gastrointestinal oncology · 2014Review
- Management controversies in Barrett's oesophagus.Journal of gastroenterology · 2014Review
- Ablative therapies for Barrett's esophagus.Current gastroenterology reports · 2011Review
Corrections and comments
- Commented on by
- Commented on by
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMany modalities have been used to ablate Barrett's oesophagus (BO). However, long term results and comparative effectiveness are unknown.
aimsOur aim was to compare the long term efficacy of achieving complete reversal (endoscopic and histological) between multipolar electrocoagulation (MPEC) and argon plasma coagulation (APC) in BO patients and assess factors influencing successful ablation.
methodsPatients with BO, 2-6 cm long, underwent 24 hour pH testing on proton pump inhibitor (PPI) therapy. Patients were then randomised by BO length to undergo ablation with MPEC or APC every 4-8 weeks until endoscopic reversal or maximal of six treatment sessions.
resultsThirty five BO patients have been followed for at least two years following endoscopic ablation, 16 treated with MPEC and 19 with APC. There was complete reversal of BO in 24 patients (69%); 75% with MPEC and 63% with APC (p = 0.49). There was no difference in the number of sessions required in the two groups. There was no difference in age, pH results, BO length, PPI dose, or hiatal hernia size between patients with and without complete reversal. One patient developed an oesophageal stricture but there were no major complications such as bleeding or perforation.
conclusionsIn BO patients treated with MPEC or APC in combination with acid suppression, at long term follow up, complete reversal of BO can be maintained in approximately 70% of patients, irrespective of the technique. There are no predictors associated with achieving complete reversal of BO. Continued surveillance is still indicated in the post ablative setting. As yet, these techniques are not ready for clinical application (other than for high grade dysplasia or early oesophageal adenocarcinoma) and cannot be offered outside the research arena.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.