ArticlePlant physiology2006
Clarification of pathway-specific inhibition by Fourier transform ion cyclotron resonance/mass spectrometry-based metabolic phenotyping studies.
Article in Plant physiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 105 citations in OpenAlex.
- Seed Metabolome Analysis of a Transgenic Rice Line Expressing Cholera Toxin B-subunit.Scientific reports · 2017Article
- Integration of omics approaches to understand oil/protein content during seed development in oilseed crops.Plant cell reports · 2017Review
- Metabolite extraction for high-throughput FTICR-MS-based metabolomics of grapevine leaves.EuPA open proteomics · 2016Article
- Metabolic Profiling of Developing Pear Fruits Reveals Dynamic Variation in Primary and Secondary Metabolites, Including Plant Hormones.PloS one · 2015Article
- Integrated analysis of transcriptome and metabolome of Arabidopsis albino or pale green mutants with disrupted nuclear-encoded chloroplast proteins.Plant molecular biology · 2014Article
- A stable-isotope mass spectrometry-based metabolic footprinting approach to analyze exudates from phytoplankton.Marine drugs · 2013Article
- Bioanalysis of eukaryotic organelles.Chemical reviews · 2013Review
- Omics methods for probing the mode of action of natural and synthetic phytotoxins.Journal of chemical ecology · 2013Review
- Data Mining Methods for Omics and Knowledge of Crude Medicinal Plants toward Big Data Biology.Computational and structural biotechnology journal · 2013Review
- High-throughput cryopreservation of plant cell cultures for functional genomics.Plant & cell physiology · 2012Article
- Recent advances of metabolomics in plant biotechnology.Plant biotechnology reports · 2012Article
- AMDORAP: non-targeted metabolic profiling based on high-resolution LC-MS.BMC bioinformatics · 2011Article
- Assessment of metabolome annotation quality: a method for evaluating the false discovery rate of elemental composition searches.PloS one · 2009Article
- Temporally resolved GC-MS-based metabolic profiling of herbicide treated plants treated reveals that changes in polar primary metabolites alone can distinguish herbicides of differing mode of action.Metabolomics : Official journal of the Metabolomic Society · 2009Article
- A signal filtering method for improved quantification and noise discrimination in fourier transform ion cyclotron resonance mass spectrometry-based metabolomics data.Journal of the American Society for Mass Spectrometry · 2009Article
- Application of GC-MS for the detection of lipophilic compounds in diverse plant tissues.Plant methods · 2009Article
- MS/MS spectral tag-based annotation of non-targeted profile of plant secondary metabolites.The Plant journal : for cell and molecular biology · 2009Article
- How large is the metabolome? A critical analysis of data exchange practices in chemistry.PloS one · 2009Article
- Metabolomics approach for determining growth-specific metabolites based on Fourier transform ion cyclotron resonance mass spectrometry.Analytical and bioanalytical chemistry · 2008Article
- Metabolite annotations based on the integration of mass spectral information.The Plant journal : for cell and molecular biology · 2008Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have developed a metabolic profiling scheme based on direct-infusion Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR/MS). The scheme consists of: (1) reproducible data collection under optimized FT-ICR/MS analytical conditions; (2) automatic mass-error correction and multivariate analyses for metabolome characterization using a newly developed metabolomics tool (DMASS software); (3) identification of marker metabolite candidates by searching a species-metabolite relationship database, KNApSAcK; and (4) structural analyses by an MS/MS method. The scheme was applied to metabolic phenotyping of Arabidopsis (Arabidopsis thaliana) seedlings treated with different herbicidal chemical classes for pathway-specific inhibitions. Arabidopsis extracts were directly infused into an electrospray ionization source on an FT-ICR/MS system. Acquired metabolomics data were comprised of mass-to-charge ratio values with ion intensity information subjected to principal component analysis, and metabolic phenotypes from the herbicide treatments were clearly differentiated from those of the herbicide-free treatment. From each herbicide treatment, candidate metabolites representing such metabolic phenotypes were found through the KNApSAcK database search. The database search and MS/MS analyses suggested dose-dependent accumulation patterns of specific metabolites including several flavonoid glycosides. The metabolic phenotyping scheme on the basis of FT-ICR/MS coupled with the DMASS program is discussed as a general tool for high throughput metabolic phenotyping studies.
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