ArticlePlant physiology2006
Down-regulation of the 26S proteasome subunit RPN9 inhibits viral systemic transport and alters plant vascular development.
Article in Plant physiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 60 citations in OpenAlex.
- Tomato Chlorotic Virus Minor Coat Protein Interferes With the Host Proteasome Function by Competitive Disruption of SlPAD1-SlPA4 Interaction to Enhance Viral Infection.Molecular plant pathology · 2025Article
- Phloem sap from melon plants contains extracellular vesicles that carry active proteasomes which increase in response to aphid infestation.Journal of extracellular vesicles · 2024Article
- Active protein ubiquitination regulates xylem vessel functionality.The Plant cell · 2024Article
- Ubiquitinated DA1 negatively regulates vascular cambium activity through modulating the stability of WOX4 in Populus.The Plant cell · 2022Article
- Comparative Transcriptome Analysis of Two Cucumber Cultivars with Different Sensitivity to Cucumber Mosaic Virus Infection.Pathogens (Basel, Switzerland) · 2020Article
- Co-suppression of NbClpC1 and NbClpC2 alters plant morphology with changed hormone levels in Nicotiana benthamiana.Plant cell reports · 2019Article
- Genetic analysis of a Piezo-like protein suppressing systemic movement of plant viruses in Arabidopsis thaliana.Scientific reports · 2019Article
- Plant immunity against viruses: antiviral immune receptors in focus.Annals of botany · 2017Review
- Tomato 26S Proteasome subunit RPT4a regulates ToLCNDV transcription and activates hypersensitive response in tomato.Scientific reports · 2016Article
- Arabidopsis PROTEASOME REGULATOR1 is required for auxin-mediated suppression of proteasome activity and regulates auxin signalling.Nature communications · 2016Article
- Solution structure of yeast Rpn9: insights into proteasome lid assembly.The Journal of biological chemistry · 2015Article
- Accumulation of high contents of free amino acids in the leaves of Nicotiana benthamiana by the co-suppression of NbClpC1 and NbClpC2 genes.Plant cell reports · 2015Article
- Article
- Fine mapping of the major Soybean dwarf virus resistance gene Rsdv1 of the soybean cultivar 'Wilis'.Breeding science · 2013Article
- The cyclophilin CYP20-2 modulates the conformation of BRASSINAZOLE-RESISTANT1, which binds the promoter of FLOWERING LOCUS D to regulate flowering in Arabidopsis.The Plant cell · 2013Article
- Plant immune responses against viruses: how does a virus cause disease?The Plant cell · 2013Review
- Article
- Viral and cellular factors involved in Phloem transport of plant viruses.Frontiers in plant science · 2013Article
- The unfolded protein response is triggered by a plant viral movement protein.Plant physiology · 2011Article
- The ubiquitin/26S proteasome system in plant-pathogen interactions: a never-ending hide-and-seek game.Molecular plant pathology · 2010Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plant viruses utilize the vascular system for systemic movement. The plant vascular network also transports water, photosynthates, and signaling molecules and is essential for plant growth. However, the molecular mechanisms governing vascular development and patterning are still largely unknown. From viral transport suppressor screening using virus-induced gene silencing, we identified a 26S proteasome subunit, RPN9, which is required for broad-spectrum viral systemic transport. Silencing of RPN9 in Nicotiana benthamiana inhibits systemic spread of two taxonomically distinct viruses, Tobacco mosaic virus and Turnip mosaic virus. The 26S proteasome is a highly conserved eukaryotic protease complex controlling many fundamental biochemical processes, but the functions of many 26S proteasome regulatory subunits, especially in plants, are still poorly understood. We demonstrate that the inhibition of viral systemic transport after RPN9 silencing is largely due to alterations in the vascular tissue. RPN9-silenced plants display extra leaf vein formation with increased xylem and decreased phloem. We further illustrate that RPN9 functions at least in part through regulation of auxin transport and brassinosteroid signaling, two processes that are crucial for vascular formation. We propose that RPN9 regulates vascular formation by targeting a subset of regulatory proteins for degradation. The brassinosteroid-signaling protein BZR1 is one of the targets.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.