ArticleThe American journal of pathology1990
Changing patterns of keratin expression during progression of cervical intraepithelial neoplasia.
Article in The American journal of pathology, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 153 citations in OpenAlex.
- Topical treatment of ichthyoses and Darier's disease with 13-cis-retinoic acid. A clinical and immunohistochemical study.Archives of dermatological research · 1993Trial
- Modeling and validating three dimensional human normal cervix and cervical cancer tissues in vitro.Journal of biomedical research · 2017Article
- Immunohistochemistry, a valuable tool in detection of cervical lymph node micrometastases in head and neck squamous cell carcinoma: a prospective study.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2013Article
- Keratin 8 expression in colon cancer associates with low faecal butyrate levels.BMC gastroenterology · 2011Article
- E1--E4-mediated keratin phosphorylation and ubiquitylation: a mechanism for keratin depletion in HPV16-infected epithelium.Journal of cell science · 2010Article
- Article
- Immunological profiling of a panel of human ovarian cancer cell lines.Cancer immunology, immunotherapy : CII · 2008Article
- The molecular mechanisms used by Neisseria gonorrhoeae to initiate infection differ between men and women.Clinical microbiology reviews · 2004Review
- Neisseria gonorrhoeae elicits membrane ruffling and cytoskeletal rearrangements upon infection of primary human endocervical and ectocervical cells.Infection and immunity · 2000Article
- Differential expression of keratins 10, 17, and 19 in normal cervical epithelium, cervical intraepithelial neoplasia, and cervical carcinoma.Journal of clinical pathology · 1999Article
- Characterization of keratin and cell cycle protein expression in cell lines from squamous intraepithelial lesions progressing towards a malignant phenotype.British journal of cancer · 1998Article
- Dedifferentiation of atrial cardiomyocytes as a result of chronic atrial fibrillation.The American journal of pathology · 1997Article
- Multiparameter flow cytometric characterization of epidermal cell suspensions prepared from normal and hyperproliferative human skin using an optimized thermolysin-trypsin protocol.Archives of dermatological research · 1996Article
- Two- and three-dimensional demonstrations of morphological alterations of early anagen hair follicle with special reference to the bulge area.Archives of dermatological research · 1996Article
- Cytokeratin intermediate filament expression in benign and malignant breast disease.Journal of clinical pathology · 1995Article
- Protein and mRNA expression of simple epithelial keratins in normal, dysplastic, and malignant oral epithelia.The American journal of pathology · 1994Article
- Cytokeratin distribution and functional properties of growth hormone-producing pituitary adenomas.Endocrine pathology · 1994Article
- Cushing's syndrome caused by an ectopic pituitary adenoma of the sphenoid sinus: Adrenal crisis after partial resections of the adenoma.Endocrine pathology · 1994Article
- Culture and characterisation of human urothelium in vivo and in vitro.Urological research · 1994Article
- Cytokeratin expression and acetowhite change in cervical epithelium.Journal of clinical pathology · 1994Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The expression of keratins in normal cervical epithelia, metaplastic epithelium, and cervical intraepithelial neoplasia (CIN) grades I, II, and III is investigated with a panel of keratin polypeptide-specific monoclonal antibodies. This approach allowed the detection of individual keratins 4, 7, 8, 10, 13, 14, 18, and 19 at the single-cell level. By using an antibody recognizing keratins 5 and 8 (RCK 102) and two antibodies specific for keratin 8 (CAM 5.2 and M 20), it was also possible to derive information on the distribution of keratin 5. Our results show that during immature squamous metaplasia there is an acquisition of keratins typical of squamous epithelium, ie, keratins 4, 5, 13, and 14. This process continues during further differentiation to mature squamous metaplasia. In premalignant lesions the expression pattern of the progenitor reserve cells and immature squamous metaplastic epithelium is partly conserved. However, in most cases an induction in the expression of the keratins 4, 13, and 14 was observed. Furthermore, CIN III shows a more extensive expression of keratins typical of simple epithelia, ie, keratins 8 and 18, as compared to CIN I and CIN II.
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1690513PMC1877502W2118724423What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.