ReviewBiochimica et biophysica acta2006
Factors influencing the energetics of electron and proton transfers in proteins. What can be learned from calculations.
Review in Biochimica et biophysica acta, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
41 citing papers in PubMed, 98 citations in OpenAlex.
- Kinetic and Potentiometric Characteristics of Ferredoxin: NADPInternational journal of molecular sciences · 2026Article
- Molecular Cloning, Optimization of Expression and Functional Characterization of the Global Transcriptional Regulator MosR (Rv0348) of Mycobacterium tuberculosis.Applied biochemistry and biotechnology · 2025Article
- Article
- Role of Protonation States in the Stability of Molecular Dynamics Simulations of High-Resolution Membrane Protein Structures.The journal of physical chemistry. B · 2024Article
- Computational Approach for Probing Redox Potential for Iron-Sulfur Clusters in Photosystem I.Biology · 2022Article
- Heme Protein Binding of Sulfonamide Compounds: A Correlation Study by Spectroscopic, Calorimetric, and Computational Methods.ACS omega · 2022Article
- Protein Motifs for Proton Transfers That Build the Transmembrane Proton Gradient.Frontiers in chemistry · 2021Review
- Catalytic Site pJournal of chemical information and modeling · 2020Article
- pH-Dependent Protonation of the Phl p 6 Pollen Allergen Studied by NMR and cpH-aMD.Journal of chemical theory and computation · 2019Article
- A Membrane-Bound Cytochrome EnablesmBio · 2019Article
- Halorhodopsin pumps Cl- and bacteriorhodopsin pumps protons by a common mechanism that uses conserved electrostatic interactions.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Metalloproteins containing cytochrome, iron-sulfur, or copper redox centers.Chemical reviews · 2014Review
- Alternative delivery of male accessory gland products.Frontiers in zoology · 2014Article
- Electrostatic effects on proton coupled electron transfer in oxomanganese complexes inspired by the oxygen-evolving complex of photosystem II.The journal of physical chemistry. B · 2013Article
- Modeling and simulation of ion channels.Chemical reviews · 2012Review
- Evolving the [myoglobin, cytochrome b(5)] complex from dynamic toward simple docking: charging the electron transfer reactive patch.Biochemistry · 2012Article
- How simple can a model of an empty viral capsid be? Charge distributions in viral capsids.Journal of biological physics · 2012Article
- Blind prediction of host-guest binding affinities: a new SAMPL3 challenge.Journal of computer-aided molecular design · 2012Article
- pKa modulation of the acid/base catalyst within GH32 and GH68: a role in substrate/inhibitor specificity?PloS one · 2012Article
- pH-Dependent conformational changes in proteins and their effect on experimental pK(a)s: the case of Nitrophorin 4.PLoS computational biology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
A protein structure should provide the information needed to understand its observed properties. Significant progress has been made in developing accurate calculations of acid/base and oxidation/reduction reactions in proteins. Current methods and their strengths and weaknesses are discussed. The distribution and calculated ionization states in a survey of proteins is described, showing that a significant minority of acidic and basic residues are buried in the protein and that most of these remain ionized. The electrochemistry of heme and quinones are considered. Proton transfers in bacteriorhodopsin and coupled electron and proton transfers in photosynthetic reaction centers, 5-coordinate heme binding proteins and cytochrome c oxidase are highlighted as systems where calculations have provided insight into the reaction mechanism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.