ArticleBiochemical and biophysical research communications2006
Cell-based chemical genetic screen identifies damnacanthal as an inhibitor of HIV-1 Vpr induced cell death.
Article in Biochemical and biophysical research communications, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 15 papers.
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15 citing papers in PubMed, 55 citations in OpenAlex.
- Article
- Review
- Anti-Vpr activities of sesqui- and diterpenoids from the roots and rhizomes of Kaempferia candida.Journal of natural medicines · 2021Article
- Bioactive Compounds from Medicinal Plants in Myanmar.Progress in the chemistry of organic natural products · 2021Article
- Computational studies reveal mechanism by which quinone derivatives can inhibit SARS-CoV-2. Study of embelin and two therapeutic compounds of interest, methyl prednisolone and dexamethasone.Journal of infection and public health · 2020Article
- Three new quassinoids isolated from the wood of Picrasma javanica and their anti-Vpr activities.Journal of natural medicines · 2020Article
- Effects of Damnacanthal and Nordamnacanthal on Proliferation, Apoptosis, and Migration of Oral Squamous Cell Carcinoma CellsAsian Pacific journal of cancer prevention : APJCP · 2017Article
- Naturally occurring Vpr inhibitors from medicinal plants of Myanmar.Journal of natural medicines · 2017Review
- The HIV-1 Vpr Protein: A Multifaceted Target for Therapeutic Intervention.International journal of molecular sciences · 2017Review
- Glucocorticoids suppress renal cell carcinoma progression by enhancing Na,K-ATPase beta-1 subunit expression.PloS one · 2015Article
- Development of a robust cell-based high-throughput screening assay to identify targets of HIV-1 viral protein R dimerization.Drug design, development and therapy · 2013Article
- The Continuing Evolution of HIV-1 Therapy: Identification and Development of Novel Antiretroviral Agents Targeting Viral and Cellular Targets.Molecular biology international · 2012Article
- Interactions between human immunodeficiency virus (HIV)-1 Vpr expression and innate immunity influence neurovirulence.Retrovirology · 2011Article
- Vipirinin, a coumarin-based HIV-1 Vpr inhibitor, interacts with a hydrophobic region of VPR.The Journal of biological chemistry · 2011Article
- Virion-associated Vpr of human immunodeficiency virus type 1 triggers activation of apoptotic events and enhances fas-induced apoptosis in human T cells.Journal of virology · 2009Article
Corrections and comments
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- Erratum issued
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Viral protein R (Vpr), one of the human immunodeficiency virus type 1 (HIV-1) accessory proteins, contributes to multiple cytopathic effects, G2 cell cycle arrest and apoptosis. The mechanisms of Vpr have been intensely studied because it is believed that they underlie HIV-1 pathogenesis. We here report a cell-based small molecule screen on Vpr induced cell death in the context of HIV-1 infection. From the screen of 504 bioactive compounds, we identified damnacanthal (Dam), a component of noni [corrected] as an inhibitor of Vpr induced cell death. Our studies illustrate a novel efficient platform for drug discovery and development in anti-HIV therapy which should also be applicable to other viruses.
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