Evidence map›Paper›PMID 16904339›Full record

ArticleJournal of the American Society for Mass Spectrometry2006

Probing RNA hairpins with cobalt(III)hexammine and electrospray ionization mass spectrometry.

Jason W Kieltyka, Christine S Chow

Abstract read
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In one paragraph

Article in Journal of the American Society for Mass Spectrometry, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. May the Best Molecule Win: Competition ESI Mass Spectrometry.International journal of molecular sciences · 2015
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Jason W KieltykaDepartment of Chemistry, Wayne State University, 5101 Cass Avenue, 48202, Detroit, MI, USA.
Christine S ChowDepartment of Chemistry, Wayne State University, 5101 Cass Avenue, 48202, Detroit, MI, USA. csc@chem.wayne.edu.

Funding

A Study of Site-Specifically Modified RNAsR01GM054632 · NIGMS · WAYNE STATE UNIVERSITY · PI CHOW, CHRISTINE S · 2003 to 2006
$917k
SITE SPECIFICALLY MODIFIED RNASR29GM054632 · NIGMS · WAYNE STATE UNIVERSITY · PI CHOW, CHRISTINE S · 1997 to 2001
$217k
NIGMS NIH HHS GM54632
6 · The paper itself

Abstract

In this work, electrospray ionization mass spectrometry (ESI MS) was employed to study the interactions of cobalt(III) hexammine, Co(NH3)6(3+), with five RNA hairpins representing the 790 loop of 16S ribosomal RNA and 1920 loop of 23S ribosomal RNA. The RNAs varied in mismatch identity (G.U versus A.C) and level of base modification (pseudouridine versus uridine). Co(NH3)6(3+) binding was observed with the four RNA hairpins that contained a G.U wobble pair in the stem region. ESI MS revealed 1:1 and 1:2 complex formation with all RNAs. Weaker binding was observed with the fifth RNA hairpin that contained an A.C wobble pair in the stem region. The effects of pH on Co(NH3)6(3+) binding were also examined.

Indexed as

Antineoplastic AgentsChemical PhenomenaChemistry, PhysicalChromatography, High Pressure LiquidCobaltEscherichia coliHydrogen-Ion ConcentrationIndicators and ReagentsNucleic Acid ConformationRibosomesRNARNA, BacterialRNA, Ribosomal, 23SSolutionsSpectrometry, Mass, Electrospray IonizationAntineoplastic AgentsCobalthexaamminecobalt(II)Indicators and ReagentsRNARNA, BacterialRNA, Ribosomal, 23SSolutions

Identifiers

PMID16904339

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.