ArticleJournal of the American Society for Mass Spectrometry2006
Use of a double resonance electron capture dissociation experiment to probe fragment intermediate lifetimes.
Article in Journal of the American Society for Mass Spectrometry, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed.
- Practical Effects of Intramolecular Hydrogen Rearrangement in Electron Transfer Dissociation-Based Proteomics.Journal of the American Society for Mass Spectrometry · 2022Article
- Metal Ion Binding to the Amyloid β Monomer Studied by Native Top-Down FTICR Mass Spectrometry.Journal of the American Society for Mass Spectrometry · 2019Article
- Hydrogen-Deuterium Exchange and Electron Capture Dissociation to Interrogate the Conformation of Gaseous Melittin Ions.Journal of the American Society for Mass Spectrometry · 2019Article
- Radical solutions: Principles and application of electron-based dissociation in mass spectrometry-based analysis of protein structure.Mass spectrometry reviews · 2018Review
- Replacing HChemical science · 2018Article
- De Novo Glycan Sequencing by Electronic Excitation Dissociation and Fixed-Charge Derivatization.Analytical chemistry · 2018Article
- Probing the Gaseous Structure of a β-Hairpin Peptide with H/D Exchange and Electron Capture Dissociation.Journal of the American Society for Mass Spectrometry · 2017Article
- Influence of metal-peptide complexation on fragmentation and inter-fragment hydrogen migration in electron transfer dissociation.Journal of the American Society for Mass Spectrometry · 2014Article
- Study of an unusual advanced glycation end-product (AGE) derived from glyoxal using mass spectrometry.Journal of the American Society for Mass Spectrometry · 2014Article
- Gas-phase structure of amyloid-β (12-28) peptide investigated by infrared spectroscopy, electron capture dissociation and ion mobility mass spectrometry.Journal of the American Society for Mass Spectrometry · 2013Article
- Does Electron Capture Dissociation Cleave Protein Disulfide Bonds?ChemistryOpen · 2012Article
- Charge-site-dependent dissociation of hydrogen-rich radical peptide cations upon vacuum UV photoexcitation.Chemistry (Weinheim an der Bergstrasse, Germany) · 2012Article
- The early life of a peptide cation-radical. Ground and excited-state trajectories of electron-based peptide dissociations during the first 330 femtoseconds.Journal of the American Society for Mass Spectrometry · 2012Article
- Coordination sphere tuning of the electron transfer dissociation behavior of Cu(II)-peptide complexes.Journal of the American Society for Mass Spectrometry · 2012Article
- Dissociation channel dependence on peptide size observed in electron capture dissociation of tryptic peptides.Journal of the American Society for Mass Spectrometry · 2011Article
- Topoisomer differentiation of molecular knots by FTICR MS: lessons from class II lasso peptides.Journal of the American Society for Mass Spectrometry · 2011Article
- Influence of charge state and amino acid composition on hydrogen transfer in electron capture dissociation of peptides.Journal of the American Society for Mass Spectrometry · 2010Article
- Charge remote fragmentation in electron capture and electron transfer dissociation.Journal of the American Society for Mass Spectrometry · 2010Article
- Identification of aspartic and isoaspartic acid residues in amyloid beta peptides, including Abeta1-42, using electron-ion reactions.Analytical chemistry · 2009Article
- Simultaneous collision induced dissociation of the charge reduced parent ion during electron capture dissociation.Analytical chemistry · 2009Article
Corrections and comments
- Erratum issued
Authors and funding
3 authors.
Funding
Abstract
The relative abundances of fragment ions in electron capture dissociation (ECD) are often greatly affected by the secondary and tertiary structures of the precursor ion, and have been used to derive the gas-phase conformations of the protein ions. In this study, it is found that resonance ejection of the charge reduced molecular ion during ECD resulted in significant changes in many fragment ion populations. The ratio of the ion peak intensities in the double resonance (DR)-ECD to that in the normal ECD experiment can be used to calculate the lifetime of the radical intermediates from which these fragments are derived. These lifetimes are often in the ms range, a time sufficiently long to facilitate multiple free radical rearrangements. These ratios correlate with the intramolecular noncovalent interactions in the precursor ion, and can be used to deduce information about the gas-phase conformation of peptide ions. DR-ECD experiments can also provide valuable information on ECD mechanisms, such as the importance of secondary electron capture and the origin of c./z ions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.