ReviewDrugs2006
Experience with remifentanil in neonates and infants.
Review in Drugs, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Sedation of newborn infants for the INSURE procedure, are we sure?BioMed research international · 2013Pooled it
- Remifentanil/midazolam versus fentanyl/midazolam for analgesia and sedation of mechanically ventilated neonates and young infants: a randomized controlled trial.Intensive care medicine · 2012Trial
- Remifentanil and propofol for weaning of mechanically ventilated pediatric intensive care patients.European journal of pediatrics · 2011Trial
- Pharmacological therapy of neonatal analgosedation: current status, dilemmas, and perspectives.Frontiers in pediatrics · 2026Review
- Population Pharmacokinetic Modeling of Remifentanil in Infants with Unrepaired Tetralogy of Fallot.European journal of drug metabolism and pharmacokinetics · 2019Article
- Efficacy and Safety Aspects of Remifentanil Sedation for Intubation in Neonates: A Retrospective Study.Frontiers in pediatrics · 2019Article
- Use of remifentanil in general anesthesia for neonatal non-cardiac surgery: a case series.JA clinical reports · 2018Article
- Correction to: Pharmacokinetics of Fentanyl and Its Derivatives in Children: A Comprehensive Review.Clinical pharmacokinetics · 2018Article
- Pharmacokinetics of Fentanyl and Its Derivatives in Children: A Comprehensive Review.Clinical pharmacokinetics · 2018Review
- Remifentanil: applications in neonates.Journal of anesthesia · 2016Review
- Anesthetic use in newborn infants: the urgent need for rigorous evaluation.Pediatric research · 2015Review
- Pain management in newborns.Clinics in perinatology · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Remifentanil is a relatively new synthetic opioid, which is not licensed worldwide for neonates and infants. Because of its unique pharmacokinetic properties with a short recovery profile, it could be the ideal opioid for neonates and infants, who are especially sensitive to respiratory depression by opioids. Therefore, we conducted a MEDLINE search on all articles dealing with the use of remifentanil in this important subgroup of patients. Most experience with remifentanil in neonates and infants is as maintenance anaesthesia during surgery. In approximately 300 neonates and infants, remifentanil proved to be an effective and safely used opioid for this indication. However, very limited data exist on remifentanil for analgesia and sedation of mechanically ventilated paediatric intensive care patients. Further research with remifentanil in neonates and infants should focus on this group of patients because remifentanil, with its very short context-sensitive half-life, could result in shorter extubation times compared with commonly used opioids such as morphine or fentanyl.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.