ArticleThe Journal of investigative dermatology2007
Loss of the acyl-CoA binding protein (Acbp) results in fatty acid metabolism abnormalities in mouse hair and skin.
Article in The Journal of investigative dermatology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 47 citations in OpenAlex.
- Recovery Effects of Oral Supplementation with Polar Lipid-Rich Wheat Extracts on Acute Telogen Effluvium: A Randomized Double-Blind Placebo-Controlled Study.Clinical, cosmetic and investigational dermatology · 2025Article
- Untargeted hair lipidomics: comprehensive evaluation of the hair-specific lipid signature and considerations for retrospective analysis.Analytical and bioanalytical chemistry · 2023Article
- From benzodiazepines to fatty acids and beyond: revisiting the role of ACBP/DBI.Trends in endocrinology and metabolism: TEM · 2021Review
- Differential Stabilities of Mefloquine-Bound Human andACS omega · 2021Article
- Transcriptomics of Tasmanian Devil (Genes · 2019Article
- Genetically modified laboratory mice with sebaceous glands abnormalities.Cellular and molecular life sciences : CMLS · 2016Review
- Translocator Protein (TSPO) Affects Mitochondrial Fatty Acid Oxidation in Steroidogenic Cells.Endocrinology · 2016Article
- Secreted Acb1 Contributes to the Yeast-to-Hypha Transition in Cryptococcus neoformans.Applied and environmental microbiology · 2016Article
- Plant Cytosolic Acyl-CoA-Binding Proteins.Lipids · 2016Review
- Minireview: translocator protein (TSPO) and steroidogenesis: a reappraisal.Molecular endocrinology (Baltimore, Md.) · 2015Review
- Strain-dependent brain defects in mouse models of primary ciliary dyskinesia with mutations in Pcdp1 and Spef2.Neuroscience · 2014Article
- Endogenous positive allosteric modulation of GABA(A) receptors by diazepam binding inhibitor.Neuron · 2013Article
- Requirement of fatty acid transport protein 4 for development, maturation, and function of sebaceous glands in a mouse model of ichthyosis prematurity syndrome.The Journal of biological chemistry · 2013Article
- The acyl-CoA binding protein is required for normal epidermal barrier function in mice.Journal of lipid research · 2012Article
- Role of fatty acid transporters in epidermis: Implications for health and disease.Dermato-endocrinology · 2011Article
- Disruption of the acyl-CoA-binding protein gene delays hepatic adaptation to metabolic changes at weaning.The Journal of biological chemistry · 2011Article
- Acyl-CoA binding protein gene ablation induces pre-implantation embryonic lethality in mice.Lipids · 2010Article
- Cdk5rap2 regulates centrosome function and chromosome segregation in neuronal progenitors.Development (Cambridge, England) · 2010Article
- Lipids to the top of hair biology.The Journal of investigative dermatology · 2010Article
- Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Proper fatty acid metabolism is critical for hair and skin development and maintenance. The acyl-CoA binding protein (Acbp) is a widely expressed protein that binds long-chain fatty acyl-CoA esters and plays a role in fatty acyl-CoA transport and pool formation. However, loss of function of Acbp in the whole animal has not been investigated. Here, we show that deletion of Acbp in mouse results in sebocyte hyperplasia and sparse, matted hair with a greasy appearance. Consistent with these gross abnormalities, Acbp is highly expressed in the pilosebaceous units of mouse skin as determined by Northern analysis and in situ hybridization. Loss of Acbp also results in fatty acid metabolism abnormalities, with hair lipid profiles showing altered levels of triacylglycerols and nearly co-migrating lipids. These data suggest that Acbp plays a role in triacylglycerol biosynthesis, and that regulation of this process is important for proper hair and skin development and maintenance in the mouse.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.