ArticleAmerican journal of respiratory cell and molecular biology2007
Silica-directed mast cell activation is enhanced by scavenger receptors.
Article in American journal of respiratory cell and molecular biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
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Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it, 99 citations in OpenAlex.
- Adverse effects and underlying mechanism of rare earth elements.Environmental health : a global access science source · 2025Pooled it
- The application of MARCO for immune regulation and treatment.Molecular biology reports · 2024Review
- The role of inflammation in silicosis.Frontiers in pharmacology · 2024Review
- Insights into the toxicological effects of nanomaterials on atherosclerosis: mechanisms involved and influence factors.Journal of nanobiotechnology · 2023Review
- Nano-silica particles synergistically IgE-mediated mast cell activation exacerbating allergic inflammation in mice.Frontiers in immunology · 2022Article
- Mast Cells Promote Nitrogen Mustard-Mediated Toxicity in the Lung Associated With Proinflammatory Cytokine and Bioactive Lipid Mediator Production.Toxicological sciences : an official journal of the Society of Toxicology · 2021Article
- Role of Nephronectin in Pathophysiology of Silicosis.International journal of molecular sciences · 2019Review
- Docosahexaenoic Acid Consumption Impedes Early Interferon- and Chemokine-Related Gene Expression While Suppressing Silica-Triggered Flaring of Murine Lupus.Frontiers in immunology · 2019Article
- Immunity to the Dual Threat of Silica Exposure andFrontiers in immunology · 2018Review
- Article
- Role of Mast Cells and Type 2 Innate Lymphoid (ILC2) Cells in Lung Transplantation.Journal of immunology research · 2018Review
- circHIPK2-mediated σ-1R promotes endoplasmic reticulum stress in human pulmonary fibroblasts exposed to silica.Cell death & disease · 2017Article
- Contribution of engineered nanomaterials physicochemical properties to mast cell degranulation.Scientific reports · 2017Article
- A mast cell-ILC2-Th9 pathway promotes lung inflammation in cystic fibrosis.Nature communications · 2017Article
- MCPIP1 Regulates Alveolar Macrophage Apoptosis and Pulmonary Fibroblast Activation After in vitro Exposure to Silica.Toxicological sciences : an official journal of the Society of Toxicology · 2016Article
- Alternative activation of macrophages and pulmonary fibrosis are modulated by scavenger receptor, macrophage receptor with collagenous structure.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2015Article
- Activation of Proinflammatory Responses in Cells of the Airway Mucosa by Particulate Matter: Oxidant- and Non-Oxidant-Mediated Triggering Mechanisms.Biomolecules · 2015Review
- Crystalline silica-induced leukotriene B4-dependent inflammation promotes lung tumour growth.Nature communications · 2015Article
- Influence of physicochemical properties of silver nanoparticles on mast cell activation and degranulation.Toxicology in vitro : an international journal published in association with BIBRA · 2015Article
- Mast Cells in Lung Homeostasis: Beyond Type I Hypersensitivity.Current respiratory medicine reviews · 2014Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Inhalation of crystalline silica results in pulmonary fibrosis and silicosis. It has been suggested that mast cells play a role in these conditions. How mast cells would influence pathology is unknown. We thus explored mast cell interactions with silica in vitro and in B6.Cg-kit(W-sh) mast cell-deficient mice. B6.Cg-kit(W-sh) mice did not develop inflammation or significant collagen deposition after instillation of silica, while C57Bl/6 wild-type mice did have these findings. Given this supporting evidence of a role for mast cells in the development of silicosis, we examined the ability of silica to activate mouse bone marrow-derived mast cells (BMMC), including degranulation (beta-hexosaminidase release); production of reactive oxygen species (ROS) and inflammatory mediators; and the effects of silica on Fc epsilon RI-dependent activation. Silica did not induce mast cell degranulation. However, TNF-alpha, IL-13, monocyte chemotactic protein-1, protease activity, and production of ROS were dose-dependently increased after silica exposure, and production was enhanced after Fc epsilon RI stimulation. This mast cell activation was inhibited by anti-inflammatory compounds. As silica mediates some effects in macrophages through scavenger receptors (SRs), we first determined that mast cells express scavenger receptors; then explored the involvement of SR-A and macrophage receptor with colleagenous structure (MARCO). Silica-induced ROS formation, apoptosis, and TNF-alpha production were reduced in BMMC obtained from SR-A, MARCO, and SR-A/MARCO knockout mice. These findings demonstrate that silica directs mast cell production of inflammatory mediators, in part through SRs, providing insight into critical events in the pathogenesis and potential therapeutic targets in silicosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.