ArticleGenome research2006
Common inheritance of chromosome Ia associated with clonal expansion of Toxoplasma gondii.
Article in Genome research, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 122 citations in OpenAlex.
- Evaluation of the impact of the first evidence-based guidelines for congenital toxoplasmosis in Armenia (Quindío) Colombia: An observational retrospective analysis.Lancet regional health. Americas · 2021Article
- Chimeric Protein Designed by Genome-Scale Immunoinformatics Enhances Serodiagnosis of Bovine Neosporosis.Journal of clinical microbiology · 2020Article
- Global selective sweep of a highly inbred genome of the cattle parasiteProceedings of the National Academy of Sciences of the United States of America · 2019Article
- Genome Wide Identification of Mutational Hotspots in the Apicomplexan Parasite Neospora caninum and the Implications for Virulence.Genome biology and evolution · 2018Article
- Review
- Article
- NextGen sequencing reveals short double crossovers contribute disproportionately to genetic diversity in Toxoplasma gondii.BMC genomics · 2014Article
- Geographic separation of domestic and wild strains of Toxoplasma gondii in French Guiana correlates with a monomorphic version of chromosome1a.PLoS neglected tropical diseases · 2014Article
- Admixture and recombination among Toxoplasma gondii lineages explain global genome diversity.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Article
- Cloning and characterization of telomerase reverse transcriptase gene in Trichinella spiralis.Parasitology research · 2012Article
- Virulence differences in Toxoplasma mediated by amplification of a family of polymorphic pseudokinases.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Article
- A novel multifunctional oligonucleotide microarray for Toxoplasma gondii.BMC genomics · 2010Article
- Phenotypic and gene expression changes among clonal type I strains of Toxoplasma gondii.Eukaryotic cell · 2009Article
- Genetic diversity of Toxoplasma gondii in animals and humans.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2009Review
- Forward genetics in Toxoplasma gondii reveals a family of rhoptry kinases that mediates pathogenesis.Eukaryotic cell · 2009Review
- Development of forward genetics in Toxoplasma gondii.International journal for parasitology · 2009Review
- Toxoplasma gondii: 25 years and 25 major advances for the field.International journal for parasitology · 2009Review
- Sexual recombination punctuated by outbreaks and clonal expansions predicts Toxoplasma gondii population genetics.International journal for parasitology · 2009Review
Corrections and comments
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Authors and funding
39 authors at 7 institutions in 3 countries.
Funding
Abstract
Toxoplasma gondii is a globally distributed protozoan parasite that can infect virtually all warm-blooded animals and humans. Despite the existence of a sexual phase in the life cycle, T. gondii has an unusual population structure dominated by three clonal lineages that predominate in North America and Europe, (Types I, II, and III). These lineages were founded by common ancestors approximately10,000 yr ago. The recent origin and widespread distribution of the clonal lineages is attributed to the circumvention of the sexual cycle by a new mode of transmission-asexual transmission between intermediate hosts. Asexual transmission appears to be multigenic and although the specific genes mediating this trait are unknown, it is predicted that all members of the clonal lineages should share the same alleles. Genetic mapping studies suggested that chromosome Ia was unusually monomorphic compared with the rest of the genome. To investigate this further, we sequenced chromosome Ia and chromosome Ib in the Type I strain, RH, and the Type II strain, ME49. Comparative genome analyses of the two chromosomal sequences revealed that the same copy of chromosome Ia was inherited in each lineage, whereas chromosome Ib maintained the same high frequency of between-strain polymorphism as the rest of the genome. Sampling of chromosome Ia sequence in seven additional representative strains from the three clonal lineages supports a monomorphic inheritance, which is unique within the genome. Taken together, our observations implicate a specific combination of alleles on chromosome Ia in the recent origin and widespread success of the clonal lineages of T. gondii.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.