ArticleThe Histochemical journal1990
Post-mortem visualization of peroxisomes in rat and in human liver.
Article in The Histochemical journal, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 16 citations in OpenAlex.
- A brief history of the human liver peroxisome.Histochemistry and cell biology · 2026Review
- Isolated dihydroxyacetonephosphate-acyl-transferase deficiency in rhizomelic chondrodysplasia punctata: clinical presentation, metabolic and histological findings.European journal of pediatrics · 1996Article
- In situ heterogeneity of peroxisomal oxidase activities: an update.The Histochemical journal · 1996Review
- A cytophotometric and electron-microscopical study on catalase activity in serial cryostat sections of rat liver.The Histochemical journal · 1995Article
- Secondary alterations of human hepatocellular peroxisomes.Journal of inherited metabolic disease · 1995Review
- Liver and chorion cytochemistry.Journal of inherited metabolic disease · 1995Article
- Ultrastructure and immunocytochemistry of hepatic peroxisomes in rhizomelic chondrodysplasia punctata.European journal of pediatrics · 1992Article
- X-linked recessive chondrodysplasia punctata with XY translocation in a stillborn fetus.Human genetics · 1991Article
- Article
- Liver pathology and immunocytochemistry in congenital peroxisomal diseases: a review.Journal of inherited metabolic disease · 1991Review
- Immunocytochemical detection of peroxisomal beta-oxidation enzymes in cryostat and paraffin sections of human post mortem liver.The Histochemical journal · 1990Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This paper describes spontaneous post-mortem changes of peroxisomal staining in normal liver and kidney of rats and in human autopsy liver. At room temperature, regional staining loss is observed at 18 h after death in rat kidney, at 24 h in human liver and at 48 h in rat liver. Preservation at 4 degrees C delays this phenomenon. In human liver, the peroxisomal volume density is decreased at both temperatures at 48 h. After freezing of fresh tissue in dry ice, peroxisomal staining is decreased homogeneously. Under the electron microscope, peroxisomal alterations suggest a loss of catalase activity. These changes do not necessarily preclude the study of peroxisomal features since, even after 48 h at room temperature, peroxisomes are still well stained in the less affected regions. Catalase and three beta-oxidation enzymes, namely acyl-CoA oxidase, bifunctional protein (with enoyl-CoA hydratase and 3-hydroxyacyl-CoA dehydrogenase) and 3-oxoacyl-CoA thiolase, could be visualized immunocytochemically in human autopsy livers up to 48 h after death. However, the study of certain peroxisomal features such a catalase activity and peroxisomal distribution, may be hampered as the post-mortem period is prolonged.
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