ReviewExpert review of proteomics2006
Photoaffinity labeling combined with mass spectrometric approaches as a tool for structural proteomics.
Review in Expert review of proteomics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed.
- Covalent Inhibitors in Antimicrobial Drug Development-Beyond β-Lactams.Molecules (Basel, Switzerland) · 2026Review
- Azidocoumarin Glycan Probes for Photoinduced Cross-Linking and In Situ Fluorescent Labeling.Bioconjugate chemistry · 2026Article
- Investigation and Development of the BODIPY-Embedded Isotopic Signature for Chemoproteomics Labeling and Targeted Profiling.Journal of the American Society for Mass Spectrometry · 2024Article
- Different chemical proteomic approaches to identify the targets of lapatinib.Journal of enzyme inhibition and medicinal chemistry · 2023Article
- Utilization of Photoaffinity Labeling to Investigate Binding of Microtubule Stabilizing Agents to P-Glycoprotein and β-Tubulin.Journal of natural products · 2022Review
- Molecular probes for the human adenosine receptors.Purinergic signalling · 2021Review
- Development of a Raltegravir-based Photoaffinity-Labeled Probe for Human Immunodeficiency Virus-1 Integrase Capture.ACS medicinal chemistry letters · 2020Article
- Photocatalytic Modification of Amino Acids, Peptides, and Proteins.Chemistry (Weinheim an der Bergstrasse, Germany) · 2019Review
- Design, synthesis and evaluation of photoactivatable derivatives of microtubule (MT)-active [1,2,4]triazolo[1,5-a]pyrimidines.Bioorganic & medicinal chemistry letters · 2018Article
- Diazirine-functionalized mannosides for photoaffinity labeling: trouble with FimH.Beilstein journal of organic chemistry · 2018Article
- Article
- Photoaffinity Labeling of the Human AACS medicinal chemistry letters · 2017Article
- Click Chemistry Reagent for Identification of Sites of Covalent Ligand Incorporation in Integral Membrane Proteins.Analytical chemistry · 2017Article
- The diverse and expanding role of mass spectrometry in structural and molecular biology.The EMBO journal · 2016Review
- Synthesis and biological evaluation of indole-2-carboxamides bearing photoactivatable functionalities as novel allosteric modulators for the cannabinoid CB1 receptor.European journal of medicinal chemistry · 2016Article
- Cross-linking and other structural proteomics techniques: how chemistry is enabling mass spectrometry applications in structural biology.Chemical science · 2016Review
- Mass spectrometric approaches to study protein structure and interactions in lyophilized powders.Journal of visualized experiments : JoVE · 2015Article
- Covalent and allosteric inhibitors of the ATPase VCP/p97 induce cancer cell death.Nature chemical biology · 2013Article
- Photocrosslinking approaches to interactome mapping.Current opinion in chemical biology · 2013Review
- A designed inhibitor of a CLC antiporter blocks function through a unique binding mode.Chemistry & biology · 2012Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Protein chemistry, such as crosslinking and photoaffinity labeling, in combination with modern mass spectrometric techniques, can provide information regarding protein-protein interactions beyond that normally obtained from protein identification and characterization studies. While protein crosslinking can make tertiary and quaternary protein structure information available, photoaffinity labeling can be used to obtain structural data about ligand-protein interaction sites, such as oligonucleotide-protein, drug-protein and protein-protein interaction. In this article, we describe mass spectrometry-based photoaffinity labeling methodologies currently used and discuss their current limitations. We also discuss their potential as a common approach to structural proteomics for providing 3D information regarding the binding region, which ultimately will be used for molecular modeling and structure-based drug design.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.