ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2006
Cerebellar cortical molecular layer inhibition is organized in parasagittal zones.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers.
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Who cites it
72 citing papers in PubMed, 114 citations in OpenAlex.
- Anatomy of Cerebro-cerebellar Circuits in Motor Control.Cerebellum (London, England) · 2026Review
- Behavioral correlates of Purkinje cell ensemble covariance.Nature communications · 2026Article
- Consensus Paper: Models of Cerebellar Functions.Cerebellum (London, England) · 2026Review
- GABA, Glx, and GSH in the cerebellum: their role in motor performance and learning across age groups.Frontiers in aging neuroscience · 2025Article
- Dysregulation of zebrin-II cell subtypes in the cerebellum is a shared feature across polyglutamine ataxia mouse models and patients.Science translational medicine · 2024Article
- Intrinsic and synaptic determinants of receptive field plasticity in Purkinje cells of the mouse cerebellum.Nature communications · 2024Article
- Purkinje-Enriched snRNA-seq in SCA7 Cerebellum Reveals Zebrin Identity Loss as a Central Feature of Polyglutamine Ataxias.bioRxiv : the preprint server for biology · 2023Article
- Postsynaptic plasticity of Purkinje cells in mice is determined by molecular identity.Communications biology · 2022Article
- Bidirectional learning in upbound and downbound microzones of the cerebellum.Nature reviews. Neuroscience · 2021Review
- Cerebellar molecular layer interneurons are dispensable for cued and contextual fear conditioning.Scientific reports · 2020Article
- Neurons of the inferior olive respond to broad classes of sensory input while subject to homeostatic control.The Journal of physiology · 2019Article
- Diverse Neuron Properties and Complex Network Dynamics in the Cerebellar Cortical Inhibitory Circuit.Frontiers in molecular neuroscience · 2019Article
- Complex Spike Wars: a New Hope.Cerebellum (London, England) · 2018Review
- Cerebellar Modules and Their Role as Operational Cerebellar Processing Units: A Consensus paper [corrected].Cerebellum (London, England) · 2018Review
- Altered levels of the splicing factor muscleblind modifies cerebral cortical function in mouse models of myotonic dystrophy.Neurobiology of disease · 2018Article
- Electrophysiological Excitability and Parallel Fiber Synaptic Properties of Zebrin-Positive and -Negative Purkinje Cells in Lobule VIII of the Mouse Cerebellar Slice.Frontiers in cellular neuroscience · 2018Article
- Studying Axon-Astrocyte Functional Interactions by 3D Two-Photon CaFrontiers in cellular neuroscience · 2018Article
- Topographic Organization of Inferior Olive Projections to the Zebrin II Stripes in the Pigeon Cerebellar Uvula.Frontiers in neuroanatomy · 2018Article
- Effect of temperature on FAD and NADH-derived signals and neurometabolic coupling in the mouse auditory and motor cortex.Pflugers Archiv : European journal of physiology · 2017Article
- Serial processing of kinematic signals by cerebellar circuitry during voluntary whisking.Nature communications · 2017Article
12 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
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Abstract
Molecular layer inhibitory interneurons generate on-beam and off-beam inhibition in the cerebellar cortex that is hypothesized to control the timing and/or spatial patterning of Purkinje cell discharge. On- and off-beam inhibition has been assumed to be spatially uniform and continuous within a folium. Using flavoprotein autofluorescence optical imaging in the mouse cerebellar cortex in vivo, this study demonstrates that the inhibition evoked by parallel fiber and peripheral stimulation results in parasagittal bands of decreases in fluorescence that correspond to zebrin II-positive bands. The parasagittal bands of decreased fluorescence are abolished by GABA(A) antagonists and reflect the activity of molecular layer interneurons on their targets. The same banding pattern was observed using Ca2+ imaging. The bands produce spatially specific decreases in the responses to peripheral input. Therefore, molecular layer inhibition is compartmentalized into zebrin II parasagittal domains that differentially modulate the spatial pattern of cerebellar cortical activity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.