ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2006
Induction of inducible cAMP early repressor expression in nucleus accumbens by stress or amphetamine increases behavioral responses to emotional stimuli.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 63 citations in OpenAlex.
- Shaping behaviors through social experience and their proposed sensitivity to stress.Learning & memory (Cold Spring Harbor, N.Y.) · 2024Review
- Topographic transcriptomics of the nucleus accumbens shell: Identification and validation of fatty acid binding protein 5 as target for cocaine addiction.Neuropharmacology · 2021Article
- Opposite regulation of conditioned place preference and intravenous drug self-administration in rodent models: Motivational and non-motivational examples.Neuroscience and biobehavioral reviews · 2020Review
- Manipulation of retinoic acid signaling in the nucleus accumbens shell alters rat emotional behavior.Behavioural brain research · 2019Article
- Glycogen synthase kinase 3 beta alters anxiety-, depression-, and addiction-related behaviors and neuronal activity in the nucleus accumbens shell.Neuropharmacology · 2017Article
- Inoculation stress hypothesis of environmental enrichment.Neuroscience and biobehavioral reviews · 2015Review
- Genesis of anxiety, depression, and ongoing abdominal discomfort in ulcerative colitis-like colon inflammation.American journal of physiology. Regulatory, integrative and comparative physiology · 2015Article
- Environmental enrichment alters protein expression as well as the proteomic response to cocaine in rat nucleus accumbens.Frontiers in behavioral neuroscience · 2014Article
- Overexpression of DeltaFosB in nucleus accumbens mimics the protective addiction phenotype, but not the protective depression phenotype of environmental enrichment.Frontiers in behavioral neuroscience · 2014Article
- Altered gene expression and spine density in nucleus accumbens of adolescent and adult male mice exposed to emotional and physical stress.Developmental neuroscience · 2014Article
- Psychological stress, cocaine and natural reward each induce endoplasmic reticulum stress genes in rat brain.Neuroscience · 2013Article
- Increased hippocampal neurogenesis and accelerated response to antidepressants in mice with specific deletion of CREB in the hippocampus: role of cAMP response-element modulator τ.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Sex differences in stress-induced social withdrawal: role of brain derived neurotrophic factor in the bed nucleus of the stria terminalis.Frontiers in behavioral neuroscience · 2013Article
- Dynamic proteomics of nucleus accumbens in response to acute psychological stress in environmentally enriched and isolated rats.PloS one · 2013Article
- Transcriptional mechanisms of drug addiction.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2012Article
- The orphan receptor GPR3 modulates the early phases of cocaine reinforcement.British journal of pharmacology · 2012Article
- Distinctive roles for amygdalar CREB in reconsolidation and extinction of fear memory.Learning & memory (Cold Spring Harbor, N.Y.) · 2012Article
- Article
- Regulator of calmodulin signaling knockout mice display anxiety-like behavior and motivational deficits.The European journal of neuroscience · 2012Article
- Molecular substrates of action control in cortico-striatal circuits.Progress in neurobiology · 2011Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previous research has shown that cAMP response element (CRE)-mediated transcription is activated in the nucleus accumbens, a major brain reward region, by a variety of environmental stimuli and contributes to neuroadaptations to these stimuli. CRE-binding protein (CREB) is the most studied activator of CRE transcription and has been implicated in this brain region as a gating mechanism for behavioral responses to emotional stimuli. Little attention, however, has been given to naturally occurring inhibitors of CRE-mediated transcription, such as the inducible cAMP early repressor (ICER), an inhibitory product of the CRE modulator gene. In the present study, we investigated the extent to which ICER is induced in the nucleus accumbens by two types of environmental stimuli, stress and amphetamine, and characterized how induction of ICER in this region affects complex behavior. We show that stress and amphetamine each induces ICER expression and that overexpression of ICER in the nucleus accumbens, using viral-mediated gene transfer, increases behavioral responses to both rewarding and aversive emotional stimuli. For example, ICER overexpression increases sensitivity to amphetamine-stimulated locomotor activity as well as to natural rewards such as sucrose and social grooming. However, ICER overexpression also increases measures of anxiety in the elevated plus maze and neophobia to novel tastes. Finally, ICER produces an antidepressant-like effect in the forced swim test, further indication of an enhanced active response to stress. These results suggest that ICER is an important mechanism for modulating CRE-mediated transcription in the nucleus accumbens.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.