ArticleThe Journal of biological chemistry2006
Mutant analysis of the Shal (Kv4) voltage-gated fast transient K+ channel in Caenorhabditis elegans.
Article in The Journal of biological chemistry, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- High-throughput behavioural phenotyping of 25 C. elegans disease models including patient-specific mutations.BMC biology · 2025Article
- Shaker/Kv1 potassium channel SHK-1 protects against pathogen infection and oxidative stress in C. elegans.PLoS genetics · 2025Article
- C. elegans enteric motor neurons fire synchronized action potentials underlying the defecation motor program.Nature communications · 2022Article
- Motor Rhythm Dissection From the Backward Circuit inFrontiers in molecular neuroscience · 2022Article
- Age-related changes in Kv4/Shal and Kv1/Shaker expression in Drosophila and a role for reactive oxygen species.PloS one · 2021Article
- Biophysical modeling of C. elegans neurons: Single ion currents and whole-cell dynamics of AWCon and RMD.PloS one · 2019Article
- Major diversification of voltage-gated K+ channels occurred in ancestral parahoxozoans.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Cell-specific proteomic analysis in Caenorhabditis elegans.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- KChIP-like auxiliary subunits of Kv4 channels regulate excitability of muscle cells and control male turning behavior during mating in Caenorhabditis elegans.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- SLO-2 potassium channel is an important regulator of neurotransmitter release in Caenorhabditis elegans.Nature communications · 2014Article
- CLHM-1 is a functionally conserved and conditionally toxic Ca2+-permeable ion channel in Caenorhabditis elegans.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Serotonin activates overall feeding by activating two separate neural pathways in Caenorhabditis elegans.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Genes down-regulated in spaceflight are involved in the control of longevity in Caenorhabditis elegans.Scientific reports · 2012Article
- Action potentials drive body wall muscle contractions in Caenorhabditis elegans.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Shal/K(v)4 channels are required for maintaining excitability during repetitive firing and normal locomotion in Drosophila.PloS one · 2011Article
- Genetic dissection of ion currents underlying all-or-none action potentials in C. elegans body-wall muscle cells.The Journal of physiology · 2011Article
- Fast inactivation of Shal (K(v)4) K+ channels is regulated by the novel interactor SKIP3 in Drosophila neurons.Molecular and cellular neurosciences · 2009Article
- The neuronal Kv4 channel complex.Neurochemical research · 2008Review
- Cumulative activation of voltage-dependent KVS-1 potassium channels.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
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Authors and funding
6 authors.
Funding
Abstract
Shal (Kv4) alpha-subunits are the most conserved among the family of voltage-gated potassium channels. Previous work has shown that the Shal potassium channel subfamily underlies the predominant fast transient outward current in Drosophila neurons (Tsunoda, S., and Salkoff, L. (1995) J. Neurosci. 15, 1741-1754) and the fast transient outward current in mouse heart muscle (Guo, W., Jung, W. E., Marionneau, C., Aimond, F., Xu, H., Yamada, K. A., Schwarz, T. L., Demolombe, S., and Nerbonne, J. M. (2005) Circ. Res. 97, 1342-1350). We show that Shal channels also play a role as the predominant transient outward current in Caenorhabditis elegans muscle. Green fluorescent protein promoter experiments also revealed SHL-1 expression in a subset of neurons as well as in C. elegans body wall muscle and in male-specific diagonal muscles. The shl-1 (ok1168) null mutant removed all fast transient outward current from muscle cells. SHL-1 currents strongly resembled Shal currents in other species except that they were active in a more depolarized voltage range. We also determined that the remaining delayed-rectifier current in cultured myocytes was carried by the Shaker ortholog SHK-1. In shl-1 (ok1168) mutants there was a significant compensatory increase in the SHK-1 current. Male shl-1 (ok1168) animals exhibited reduced mating efficiency resulting from an apparent difficulty in locating the hermaphrodite vulva. SHL-1 channels are apparently important in fine-tuning complex behaviors, such as mating, that play a crucial role in the survival and propagation of the species.
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