Evidence map›Paper›PMID 16899206›Full record

ReviewCurrent allergy and asthma reports2006

New approaches to allergen immunotherapy.

Christopher L Kepley

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current allergy and asthma reports, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.2field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Inhibitory Effects of Eriodictyol-7-Molecules (Basel, Switzerland) · 2020
    Article
  4. Article
  5. SCHOOL model and new targeting strategies.Advances in experimental medicine and biology · 2008
    Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Christopher L KepleyDepartment of Internal Medicine,Virginia Commonwealth University Health Systems,1112 East Clay Street, Richmond, VA 23298, USA. clkepley@vcu.edu
Virginia Commonwealth University · US

Funding

REGULATION OF IGE IN HEALTH AND DISEASER01AI015251 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SAXON, ANDREW · 1985 to 2007
$2.5M
NIAID NIH HHS R01-AI15251
6 · The paper itself

Abstract

Allergic diseases are common problems affecting 20% to 30% of the US population. Mast cells and basophils are the primary effector cells mediating allergic inflammation through the triggering of membrane immunoglobulin E receptors (FceRI) with antigen. Allergen immunotherapy is used as one treatment for allergic disease and results in the inhibition of mast cell and basophil responses through unknown mechanisms. In this review, we examine potential mechanisms that could result in blunted human mast cell/basophil functional responses, strategies aimed at using these mechanisms to develop new immunologically based therapies, and recent findings that have broad implications toward our understanding of how mast cells/basophils become desensitized.

Indexed as

Desensitization, ImmunologicAnimalsBasophilsHumansIntracellular Signaling Peptides and ProteinsMast CellsProtein-Tyrosine KinasesReceptors, IgEReceptors, IgGSkinSyk KinaseIntracellular Signaling Peptides and ProteinsProtein-Tyrosine KinasesReceptors, IgEReceptors, IgGSyk KinaseSYK protein, human

Identifiers

PMID16899206
OpenAlexW2024488198

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.