ReviewCurrent allergy and asthma reports2006
TACI mutation in common variable immunodeficiency and IgA deficiency.
Review in Current allergy and asthma reports, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 54 citations in OpenAlex.
- Re-evaluation of the contribution ofJournal of human immunity · 2025Article
- TACI and BTK gene analysis in predominantly antibody deficiencies among the primary immunodeficiency disorder patients in Bangladesh.Frontiers in medicine · 2025Article
- The Epidemiology and Clinical Presentations of Atopic Diseases in Selective IgA Deficiency.Journal of clinical medicine · 2021Review
- Targeted NGS Yields Plentiful Ultra-Rare Variants in Inborn Errors of Immunity Patients.Genes · 2021Article
- TNFRSF13B polymorphisms counter microbial adaptation to enteric IgA.JCI insight · 2021Article
- Innate Mechanisms in Selective IgA Deficiency.Frontiers in immunology · 2021Review
- Selective IgA Deficiency a Probable Risk of Recurrent Chest Infections in Asthmatics.Journal of asthma and allergy · 2021Article
- Update on Infections in Primary Antibody Deficiencies.Frontiers in immunology · 2021Review
- Aberrant X chromosome skewing and acquired clonal hematopoiesis in adult-onset common variable immunodeficiency.JCI insight · 2019Article
- B cell phenotypes in patients with rheumatoid arthritis relapsing after rituximab: expression of B cell-activating factor-binding receptors on B cell subsets.Clinical and experimental immunology · 2017Article
- Deficit of Anterior Pituitary Function and Variable Immune Deficiency Syndrome: A Novel Mutation.Global pediatric health · 2017Article
- Hypogammaglobulinemia in BLT humanized mice--an animal model of primary antibody deficiency.PloS one · 2014Article
- [Humoral immunodeficiency : awareness for better support].The Pan African medical journal · 2014Review
- Diagnosis and treatment of gastrointestinal disorders in patients with primary immunodeficiency.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2013Review
- Asthma and risk of selective IgA deficiency or common variable immunodeficiency: a population-based case-control study.Mayo Clinic proceedings · 2013Article
- Long-term follow-up on affinity maturation and memory B-cell generation in patients with common variable immunodeficiency.Journal of clinical immunology · 2013Article
- Educational paper: primary antibody deficiencies.European journal of pediatrics · 2011Review
- Article
- Common variable immunodeficiency: etiological and treatment issues.International archives of allergy and immunology · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Common variable immunodeficiency (CVID) is a heterogeneous primary immunodeficiency disease. Immunoglobulin A deficiency (IGAD) shares some clinical, laboratory, and genetic features with CVID and occurs with relatively greater frequency in first-degree relatives of individuals with CVID. Recently, patients with CVID and IGAD have been found to have mutations of the gene TNFRSF13B encoding the TACI (transmembrane activator and calcium-modulator and cyclophilin-ligand interactor), a member of the tumor necrosis factor-receptor superfamily. In this article, we review the various TACI mutations that have been identified so far. Although six mutations have been reported, no clear genotype-phenotype association has been shown to date. This suggests that the phenotypic expression of TACI mutation is affected by additional genetic and environmental factors. Analysis of a larger sample of patients will be needed to determine if the specific mutations are associated with a particular phenotype or predisposition to the common features of CVID and IGAD: autoimmunity, lymphoproliferation, or malignancy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.