ArticleAlcoholism, clinical and experimental research2006
Competing presynaptic and postsynaptic effects of ethanol on cerebellar purkinje neurons.
Article in Alcoholism, clinical and experimental research, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 35 citations in OpenAlex.
- Synaptic Effects Induced by Alcohol.Current topics in behavioral neurosciences · 2025Review
- Synaptic targets: Chronic alcohol actions.Neuropharmacology · 2017Review
- Viral Vector Reprogramming of Adult Resident Striatal Oligodendrocytes into Functional Neurons.Molecular therapy : the journal of the American Society of Gene Therapy · 2017Article
- Ethanol Modulates the Spontaneous Complex Spike Waveform of Cerebellar Purkinje Cells RecordedFrontiers in cellular neuroscience · 2017Article
- Electrophysiological and Immunohistochemical Evidence for an Increase in GABAergic Inputs and HCN Channels in Purkinje Cells that Survive Developmental Ethanol Exposure.Cerebellum (London, England) · 2015Article
- Mini-Review: Effects of Ethanol on GABAA Receptor-Mediated Neurotransmission in the Cerebellar Cortex--Recent Advances.Cerebellum (London, England) · 2015Review
- Synaptic effects induced by alcohol.Current topics in behavioral neurosciences · 2013Review
- Ethanol-enhanced GABA release: a focus on G protein-coupled receptors.Brain research reviews · 2011Review
- The PLC/IP 3 R/PKC pathway is required for ethanol-enhanced GABA release.Neuropharmacology · 2010Article
- Ethanol decreases Purkinje neuron excitability by increasing GABA release in rat cerebellar slices.The Journal of pharmacology and experimental therapeutics · 2008Article
- The role of protein kinase A in the ethanol-induced increase in spontaneous GABA release onto cerebellar Purkinje neurons.Journal of neurophysiology · 2008Article
- Brain regional differences in the effect of ethanol on GABA release from presynaptic terminals.The Journal of pharmacology and experimental therapeutics · 2008Article
- Ethanol modulates synaptic and extrasynaptic GABAA receptors in the thalamus.The Journal of pharmacology and experimental therapeutics · 2008Article
- The role of GABA(A) receptors in the development of alcoholism.Pharmacology, biochemistry, and behavior · 2008Review
- Ethanol enhances GABAergic transmission onto dopamine neurons in the ventral tegmental area of the rat.Alcoholism, clinical and experimental research · 2008Article
- Modulation of GABAA receptors in cerebellar granule neurons by ethanol: a review of genetic and electrophysiological studies.Alcohol (Fayetteville, N.Y.) · 2007Review
- Basis of the gabamimetic profile of ethanol.Alcoholism, clinical and experimental research · 2006Article
- Ethanol increases GABAergic transmission and excitability in cerebellar molecular layer interneurons from GAD67-GFP knock-in mice.Alcohol and alcoholism (Oxford, Oxfordshire)Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
backgroundEthanol has actions on cerebellar Purkinje neurons that can result either in a net excitation or in inhibition of neuronal activity. The present study examines the interplay of presynaptic and postsynaptic mechanisms to determine the net effect of ethanol on the neuronal firing rate of cerebellar Purkinje neurons.
methodsWhole-cell voltage-clamp recording of miniature inhibitory postsynaptic currents (mIPSCs) from Purkinje neurons in cerebellar slices was used to examine the effect of ethanol on presynapticsynaptic release of gamma-aminobutyric acid (GABA) and glutamate. Extracellular recording was used to examine the net action of both presynaptic and postsynaptic effects of ethanol on the firing rate of Purkinje neurons.
resultsUnder whole-cell voltage clamp, the frequency of bicuculline-sensitive miniature postsynaptic currents (mIPSCs) was increased dose-dependently by 25, 50, and 100 mM ethanol without any change in amplitude or decay time. Despite this evidence of increased release of GABA by ethanol, application of 50 mM ethanol caused an increase in firing in some neurons and a decrease in firing in others with a nonrandom distribution. When both glutamatergic and GABAergic influences were removed by simultaneous application of 6-cyano-7-nitroquinoxaline-2,3-dione and picrotoxin, respectively, ethanol caused only an increase in firing rate.
conclusionsThese data are consistent with a dual action of ethanol on cerebellar Purkinje neuron activity. Specifically, ethanol acts presynaptically to increase inhibition by release of GABA, while simultaneously acting postsynaptically to increase intrinsic excitatory drive.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.