ReviewPaediatric drugs2006
Diuretics in pediatrics : current knowledge and future prospects.
Review in Paediatric drugs, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Clinical practice guideline for pediatric idiopathic nephrotic syndrome 2013: general therapy.Clinical and experimental nephrology · 2015Guideline
- Furosemide versus ethacrynic acid in pediatric patients undergoing cardiac surgery: a randomized controlled trial.Critical care (London, England) · 2015Trial
- Population pharmacokinetic model of canrenone after intravenous administration of potassium canrenoate to paediatric patients.British journal of clinical pharmacology · 2012Trial
- Diuretics in pediatrics.European journal of pediatrics · 2023Review
- Accuracy of Dose Administered to Children Using Off-Labelled or Unlicensed Oral Dosage Forms.Pharmaceutics · 2021Article
- The Use of Diuretic in Mechanically Ventilated Children with Viral Bronchiolitis: a Cohort Study.Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures) · 2021Article
- Medical management of pediatric heart failure.Cardiovascular diagnosis and therapy · 2021 · on this mapReview
- Renal aspects of metabolic acid-base disorders in neonates.Pediatric nephrology (Berlin, Germany) · 2020Review
- Association Between Furosemide Exposure and Clinical Outcomes in a Retrospective Cohort of Critically Ill Children.Frontiers in pediatrics · 2020Article
- Cardiopulmonary Bypass and AKI: AKI Is Bad, So Let's Get Beyond the Diagnosis.Frontiers in pediatrics · 2019Review
- Acute kidney injury and fluid overload in infants and children after cardiac surgery.Pediatric nephrology (Berlin, Germany) · 2017Review
- Clinical pharmacology of furosemide in neonates: a review.Pharmaceuticals (Basel, Switzerland) · 2013Article
- Diuretics for very low birth weight infants in the first 28 days: a survey of the U.S. neonatologists.Journal of perinatology : official journal of the California Perinatal Association · 2011Article
- Systemic hypertension and proteinuria in childhood chronic renal parenchymal disease: role of antihypertensive drug management.Paediatric drugs · 2007Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This review summarizes current knowledge on the pharmacology, pharmacokinetics, pharmacodynamics, and clinical application of the most commonly used diuretics in children. Diuretics are frequently prescribed drugs in children. Their main indication is to reduce fluid overload in acute and chronic disease states such as congestive heart failure and renal failure. As with most drugs used in children, optimal dosing schedules are largely unknown and empirical. This is undesirable as it can potentially result in either under- or over-treatment with the possibility of unwanted effects. The pharmacokinetics of diuretics vary in the different pediatric age groups as well as in different disease states. To exert their action, all diuretics, except spironolactone, have to reach the tubular lumen by glomerular filtration and/or proximal tubular secretion. Therefore, renal maturation and function influence drug delivery and consequently pharmacodynamics. Currently advised doses for diuretics are largely based on adult pharmacokinetic and pharmacodynamic studies. Therefore, additional pharmacokinetic and pharmacodynamic studies for the different pediatric age groups are necessary to develop dosing regimens based on pharmacokinetic and pharmacodynamic models for all routes of administration.
Indexed as
Identifiers
16898855What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.