ArticleProceedings of the National Academy of Sciences of the United States of America1990
cDNA sequence for human erythrocyte ankyrin.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
47 citing papers in PubMed, 166 citations in OpenAlex.
- A Mutation in the ANK2 Gene Causing ASD and a Review of the Literature.Molecular genetics & genomic medicine · 2025Review
- Targeted next-generation sequencing identifies a novel nonsense mutation in ANK1 for hereditary spherocytosis: A case report.World journal of clinical cases · 2022Article
- Severe hyperbilirubinemia in a neonate with hereditary spherocytosis due to aWorld journal of clinical cases · 2021Article
- Mechanisms and Alterations of Cardiac Ion Channels Leading to Disease: Role of Ankyrin-B in Cardiac Function.Biomolecules · 2020Review
- Human ankyrins and their contribution to disease biology: An update.Journal of biosciences · 2020Review
- Two novel ANK1 loss-of-function mutations in Chinese families with hereditary spherocytosis.Journal of cellular and molecular medicine · 2019Article
- Ankyrins and Spectrins in Cardiovascular Biology and Disease.Frontiers in physiology · 2017Review
- Overexpression of ankyrin1 promotes pancreatic cancer cell growth.Oncotarget · 2016Article
- The cytoskeleton adaptor protein ankyrin-1 is upregulated by p53 following DNA damage and alters cell migration.Cell death & disease · 2016Article
- Hyaluronan-CD44 interaction promotes oncogenic signaling, microRNA functions, chemoresistance, and radiation resistance in cancer stem cells leading to tumor progression.Advances in cancer research · 2014Review
- Design, construction, and characterization of a second-generation DARP in library with reduced hydrophobicity.Protein science : a publication of the Protein Society · 2013Article
- Structurally similar but functionally diverse ZU5 domains in human erythrocyte ankyrin.Journal of molecular biology · 2012Article
- Orthopoxvirus genes that mediate disease virulence and host tropism.Advances in virology · 2012Article
- Review
- Proteolysis of submembrane cytoskeletal proteins ankyrin-G and αII-spectrin following diffuse brain injury: a role in white matter vulnerability at Nodes of Ranvier.Brain pathology (Zurich, Switzerland) · 2010Article
- Obscurin targets ankyrin-B and protein phosphatase 2A to the cardiac M-line.The Journal of biological chemistry · 2008Article
- Ankyrin-linked hereditary spherocytosis in an African-American kindred.American journal of hematology · 2008Article
- Molecular epitopes of the ankyrin-spectrin interaction.Biochemistry · 2008Article
- Hyaluronan-CD44 interaction activates stem cell marker Nanog, Stat-3-mediated MDR1 gene expression, and ankyrin-regulated multidrug efflux in breast and ovarian tumor cells.The Journal of biological chemistry · 2008Article
- Obscurin is a ligand for small ankyrin 1 in skeletal muscle.Molecular biology of the cell · 2003Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
The cDNA for human erythrocyte ankyrin has been isolated from a series of overlapping clones obtained from a reticulocyte cDNA library. The composite cDNA sequence has a large open reading frame of 5636 base pairs (bp) with the complete coding sequence for a polypeptide of 1879 amino acids with a predicted molecular mass of 206 kDa. The derived amino acid sequence contained 194 residues that were identical to those obtained by direct amino acid sequencing of 11 ankyrin proteolytic peptides. The primary sequence contained 23 highly homologous repeat units of 33 amino acids within the 90-kDa band 3 binding domain. Two cDNA clones showed evidence of apparent mRNA processing, resulting in the deletions of 486 bp and 135 bp, respectively. The 486-bp deletion resulted in the removal of a 16-kDa highly acidic peptide, and the smaller deletion had the effect of altering the COOH terminus of the molecule. Radiolabeled ankyrin cDNAs recognized two erythroid message sizes by RNA blot analysis, one of which was predominantly associated with early erythroid cell types. An ankyrin message was also observed in RNA from the human cerebellum by the same method. The ankyrin gene is assigned to chromosome 8 using genomic DNA from a panel of sorted human chromosomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.