ArticleJournal of neural transmission (Vienna, Austria : 1996)2007
No association between the genetic polymorphisms in the RTN4R gene and schizophrenia in the Chinese population.
Article in Journal of neural transmission (Vienna, Austria : 1996), 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 25 citations in OpenAlex.
- Identification of genetic variants of LGI1 and RTN4R (NgR1) linked to schizophrenia that are defective in NgR1-LGI1 signaling.Molecular genetics & genomic medicine · 2016Article
- Genetic variants in Nogo receptor signaling pathways may be associated with early life adversity in schizophrenia susceptibility.BBA clinical · 2015Article
- Copy number variation at 22q11.2: from rare variants to common mechanisms of developmental neuropsychiatric disorders.Molecular psychiatry · 2013Review
- Contribution of nonprimate animal models in understanding the etiology of schizophrenia.Journal of psychiatry & neuroscience : JPN · 2011Review
- Converging evidence for the Nogo-66 receptor gene in schizophrenia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Review
- Genetic variants of Nogo-66 receptor with possible association to schizophrenia block myelin inhibition of axon growth.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- Nogo-A and Nogo-66 receptor in amyotrophic lateral sclerosis.Journal of cellular and molecular medicine · 2008Review
- Nogo Receptor 1 (RTN4R) as a candidate gene for schizophrenia: analysis using human and mouse genetic approaches.PloS one · 2007Article
Corrections and comments
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Authors and funding
12 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The RTN4R gene is located in the 22q11 region and it encodes a subunit of the receptor complex (RTN4R-p75NTR) which results in neuronal growth inhibitory signals in response to Nogo-66, MAG or OMG signaling. Previous studies have suggested that RTN4R might act as a potential candidate for schizophrenia susceptibility loci. We genotyped four SNPs within the gene and conducted a case-control study and TDT analysis, involving 707 schizophrenic patients, 689 controls and 372 unrelated small nuclear families with schizophrenic offspring in the Chinese population. We examined allele and genotype frequencies and haplotype distributions in both family- and nonfamily-based samples. Our results suggest that there is no significant association between the genetic polymorphisms and schizophrenia in the Han Chinese population.
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Registered trials
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