ArticleJournal of autism and developmental disorders2007
Studying the emergence of autism spectrum disorders in high-risk infants: methodological and practical issues.
Article in Journal of autism and developmental disorders, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 94 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
94 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Parent concerns prior to an assessment of autism spectrum disorder: A systematic review.Autism : the international journal of research and practice · 2025Pooled it
- Click-evoked auditory brainstem responses and autism spectrum disorder: a meta-analytic investigation of disorder specificity.Pediatric research · 2022Pooled it
- Click-evoked auditory brainstem responses and autism spectrum disorder: A meta-analytic review.Autism research : official journal of the International Society for Autism Research · 2018Pooled it
- Early Identification of Autism Spectrum Disorder: Recommendations for Practice and Research.Pediatrics · 2015Guideline
- Pivotal response treatment for infants at-risk for autism spectrum disorders: a pilot study.Journal of autism and developmental disorders · 2013Trial
- Microbiome biomarkers in autism spectrum disorder: Toward prediction, diagnosis, and prognosis.Cell reports. Medicine · 2026Review
- Growth Trajectories of Joint Attention and Play as Predictors for Language in Young Children at Elevated Likelihood for Autism.Journal of autism and developmental disorders · 2026Article
- Investigating the Predictive Validity of the Quantitative Checklist for Autism in Toddlers and the Autism Diagnostic Observation Schedule-2 in Children at Elevated Likelihood for Autism.Journal of autism and developmental disorders · 2026Article
- Cerebrospinal fluid metabolomics in autistic regression reveals dysregulation of sphingolipids and decreased β-hydroxybutyrate.EBioMedicine · 2025Article
- Atypical functional connectivity between the amygdala and visual, salience regions in infants with genetic liability for autism.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- ASD-GResTM: Deep Learning Framework for ASD classification using Gramian Angular Field.Proceedings. IEEE International Conference on Bioinformatics and Biomedicine · 2023Article
- A Developmental Social Neuroscience Perspective on Infant Autism Interventions.Annual review of developmental psychology · 2023Article
- Oromotor skills in autism spectrum disorder: A scoping review.Autism research : official journal of the International Society for Autism Research · 2023Article
- Using developmental regression to reorganize the clinical importance of autistic atypicalities.Translational psychiatry · 2022Article
- Developmental Milestones of Infancy and Associations with Later Childhood Neurodevelopmental Outcomes in the Adolescent Brain Cognitive Development (ABCD) Study.Children (Basel, Switzerland) · 2022Article
- Signalling pathways in autism spectrum disorder: mechanisms and therapeutic implications.Signal transduction and targeted therapy · 2022Review
- Infant vocalizing and phenotypic outcomes in autism: Evidence from the first 2 years.Child development · 2022Article
- Pre-symptomatic intervention for autism spectrum disorder (ASD): defining a research agenda.Journal of neurodevelopmental disorders · 2021Review
- Observed Social Emotional Behavior at 22 Months Predicts a Later ASD Diagnosis in High-Risk Siblings.Journal of autism and developmental disorders · 2021Article
- Lack of neural evidence for implicit language learning in 9-month-old infants at high risk for autism.Developmental science · 2021Article
34 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
Abstract
Detecting early signs of autism is essential for timely diagnosis and initiation of effective interventions. Several research groups have initiated prospective studies of high-risk populations including infant siblings, to systematically collect data on early signs within a longitudinal design. Despite the potential advantages of prospective studies of young children at high-risk for autism, there are also significant methodological, ethical and practical challenges. This paper outlines several of these challenges, including those related to sampling (e.g., defining appropriate comparison groups), measurement and clinical implications (e.g., addressing the needs of infants suspected of having early signs). We suggest possible design and implementation strategies to address these various challenges, based on current research efforts in the field and previous studies involving high-risk populations.
Indexed as
Identifiers
16897376What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.