ReviewCellular and molecular neurobiology
The onset of brain injury and neurodegeneration triggers the synthesis of docosanoid neuroprotective signaling.
Review in Cellular and molecular neurobiology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 84 citations in OpenAlex.
- Marine Fish-Derived Lysophosphatidylcholine: Properties, Extraction, Quantification, and Brain Health Application.Molecules (Basel, Switzerland) · 2023Review
- SARS-CoV-2 journey to the brain with a focus on potential role of docosahexaenoic acid bioactive lipid mediators.Biochimie · 2021Review
- DHA modulates MANF and TREM2 abundance, enhances neurogenesis, reduces infarct size, and improves neurological function after experimental ischemic stroke.CNS neuroscience & therapeutics · 2020Article
- Innovative mouse model mimicking human-like features of spinal cord injury: efficacy of Docosahexaenoic acid on acute and chronic phases.Scientific reports · 2019Article
- Effects of Fish and Grape Seed Oils as Core of Haloperidol-Loaded Nanocapsules on Oral Dyskinesia in Rats.Neurochemical research · 2018Article
- Promising Metabolite Profiles in the Plasma and CSF of Early Clinical Parkinson's Disease.Frontiers in aging neuroscience · 2018Article
- Current and Emerging Technologies for Probing Molecular Signatures of Traumatic Brain Injury.Frontiers in neurology · 2017Review
- Imaging mass spectrometry reveals loss of polyunsaturated cardiolipins in the cortical contusion, hippocampus, and thalamus after traumatic brain injury.Journal of neurochemistry · 2016Article
- Dysfunctional epileptic neuronal circuits and dysmorphic dendritic spines are mitigated by platelet-activating factor receptor antagonism.Scientific reports · 2016Article
- Chronic Repetitive Mild Traumatic Brain Injury Results in Reduced Cerebral Blood Flow, Axonal Injury, Gliosis, and Increased T-Tau and Tau Oligomers.Journal of neuropathology and experimental neurology · 2016Article
- DHA but Not EPA Emulsions Preserve Neurological and Mitochondrial Function after Brain Hypoxia-Ischemia in Neonatal Mice.PloS one · 2016Article
- Docosahexaenoic acid improves behavior and attenuates blood-brain barrier injury induced by focal cerebral ischemia in rats.Experimental & translational stroke medicine · 2015Article
- Fatty acid status and its relationship to cognitive decline and homocysteine levels in the elderly.Nutrients · 2014Article
- Apolipoprotein D takes center stage in the stress response of the aging and degenerative brain.Neurobiology of aging · 2014Review
- ER stress and effects of DHA as an ER stress inhibitor.Translational stroke research · 2013Review
- Modulating the inflammatory properties of activated microglia with Docosahexaenoic acid and Aspirin.Lipids in health and disease · 2013Article
- Docosahexaenoic acid pretreatment confers protection and functional improvements after acute spinal cord injury in adult rats.Journal of neurotrauma · 2012Article
- DHA inhibits ER Ca2+ release and ER stress in astrocytes following in vitro ischemia.Journal of neurochemistry · 2012Article
- SPARC overexpression inhibits cell proliferation in neuroblastoma and is partly mediated by tumor suppressor protein PTEN and AKT.PloS one · 2012Article
- Metabolite profiles correlate closely with neurobehavioral function in experimental spinal cord injury in rats.PloS one · 2012Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bioactive lipid messengers are formed through phospholipase-mediated cleavage of specific phospholipids from membrane reservoirs. Effectors that activate the synthesis of lipid messengers, include ion channels, neurotransmitters, membrane depolarization, cytokines, and neurotrophic factors. In turn, lipid messengers regulate and interact with multiple pathways, participating in the development, differentiation, function (e.g., long-term potentiation and memory), protection, and repair of cells of the nervous system. Overall, bioactive lipids participate in the regulation of synaptic function and dysfunction. Platelet-activating factor (PAF) and COX-2-synthesized PGE(2) modulate synaptic plasticity and memory. Oxidative stress disrupts lipid signaling, fosters lipid peroxidation, and initiates and propagates neurodegeneration. Lipid messengers participate in the interactions among neurons, astrocytes, oligodendrocytes, microglia, cells of the microvasculature, and other cells. A conglomerate of interrelated cells comprises the neurovascular unit. Signaling at the neurovascular unit is clearly altered in the early stages of cerebrovascular disease as well as in neurodegenerations. Here we will provide examples of how signaling by lipids regulates critical events essential for neuronal survival. We will highlight a newly identified, DHA-derived messenger, neuroprotectin D1, which attenuates oxidative stress-induced apoptosis. The specificity and potency of this novel docosanoid (neuroprotectin D1) indicate a potentially important target for therapeutic intervention.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.