ArticleMammalian genome : official journal of the International Mammalian Genome Society2006
Identification of genetic variation and putative regulatory regions in bovine CARD15.
Article in Mammalian genome : official journal of the International Mammalian Genome Society, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 29 citations in OpenAlex.
- The Paratuberculosis Paradigm Examined: A Review of Host Genetic Resistance and Innate Immune Fitness inFrontiers in veterinary science · 2021Review
- Polymorphisms in toll-like receptor (Journal of genetics · 2018Article
- Expression of KCNQ1OT1, CDKN1C, H19, and PLAGL1 and the methylation patterns at the KvDMR1 and H19/IGF2 imprinting control regions is conserved between human and bovine.Journal of biomedical science · 2012Article
- Genes controlling vaccine responses and disease resistance to respiratory viral pathogens in cattle.Veterinary immunology and immunopathology · 2012Article
- Computational refinement of functional single nucleotide polymorphisms associated with ATM gene.PloS one · 2012Article
- Path to facilitate the prediction of functional amino acid substitutions in red blood cell disorders--a computational approach.PloS one · 2011Article
- GSEA-SNP identifies genes associated with Johne's disease in cattle.Mammalian genome : official journal of the International Mammalian Genome Society · 2010Article
- Genetic loci involved in antibody response to Mycobacterium avium ssp. paratuberculosis in cattle.PloS one · 2010Article
- Risk haplotype analysis for bovine paratuberculosis.Mammalian genome : official journal of the International Mammalian Genome Society · 2009Article
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mutations in caspase recruitment domain 15 (CARD15) are associated with susceptibility to Crohn's disease and Blau Syndrome. We performed comparative analyses of the bovine, murine, and human CARD15 transcripts to elucidate functionality of bovine CARD15 and examine its potential role in bovine disease resistance. Comparative analyses of intronic sequence across seven divergent species were performed to identify putative regulatory element binding motifs. High levels of interspecies conservation in sequence, genomic structure, and protein domains were detected indicating common functionality for CARD15 in cattle, human, and mouse. We identified species-specific regulatory elements in the 5' and 3' untranslated regions, suggesting that modes of regulation may have diverged across species. Thirty-one conserved putative regulatory element binding motifs were identified in the CARD15 intronic sequence of seven species. To assess the extent of genetic diversity within bovine CARD15, 41 individuals from two subspecies were sequenced and screened for polymorphisms. Thirty-six single nucleotide polymorphisms (SNPs) were identified. Finally, 20 subspecies-specific haplotypes were predicted with 7 and 13 unique haplotypes explaining the diversity within B. taurus taurus and B. taurus indicus animals, respectively. Strong evidence for a simple causal relationship between these SNP loci and their haplotypes with Johne's disease was not detected.
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