ArticleThe Journal of cell biology1990
Novel function for beta 1 integrins in keratinocyte cell-cell interactions.
Article in The Journal of cell biology, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers.
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Who cites it
72 citing papers in PubMed, 338 citations in OpenAlex.
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- Laminin 511 E8 fragment promotes to form basement membrane-like structure in human skin equivalents.Regenerative therapy · 2024Article
- THY1-mediated mechanisms converge to drive YAP activation in skin homeostasis and repair.Nature cell biology · 2022Article
- The Potential Role of a Surface-Modified Additive-Manufactured Healing Abutment on the Expression of Integrins α2, β1, αv, and β6 in the Peri-Implant Mucosa: A Preliminary Human Study.Life (Basel, Switzerland) · 2022Article
- Novel function for AP-1B during cell migration.Molecular biology of the cell · 2020Article
- Novel Regulation of Integrin Trafficking by Rab11-FIP5 in Aggressive Prostate Cancer.Molecular cancer research : MCR · 2018Article
- Isolation and characterization of squamous cell carcinoma-derived stem-like cells: role in tumor formation.International journal of molecular sciences · 2013Article
- Article
- Differential expressions of adhesive molecules and proteases define mechanisms of ovarian tumor cell matrix penetration/invasion.PloS one · 2011Article
- Desmosomes in developing human epidermis.Dermatology research and practice · 2010Article
- Localization and potential function of kindlin-1 in periodontal tissues.European journal of oral sciences · 2009Article
- Formation of cysts by alveolar type II cells in three-dimensional culture reveals a novel mechanism for epithelial morphogenesis.Molecular biology of the cell · 2007Article
- CD47 regulation of epithelial cell spreading and migration, and its signal transduction.Cancer science · 2006Article
- alpha3beta1 integrin-CD151, a component of the cadherin-catenin complex, regulates PTPmu expression and cell-cell adhesion.The Journal of cell biology · 2003Article
- Characterization of Porphyromonas gingivalis-induced degradation of epithelial cell junctional complexes.Infection and immunity · 2000Article
- Regulation of endothelial cell motility by complexes of tetraspan molecules CD81/TAPA-1 and CD151/PETA-3 with alpha3 beta1 integrin localized at endothelial lateral junctions.The Journal of cell biology · 1998Article
- The expression of alpha 6 and beta 4 integrin genes are differentially regulated by all-trans-retinoic acid (RA) in cultured human keratinocytes.Archives of dermatological research · 1996Article
- Integrin function: molecular hierarchies of cytoskeletal and signaling molecules.The Journal of cell biology · 1995Article
- Expression and ligand binding of alpha 2 beta 1 integrin on breast carcinoma cells.Clinical & experimental metastasis · 1995Article
- Expression of epithelial adhesion proteins and integrins in chronic inflammation.The American journal of pathology · 1995Article
12 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
We have examined the expression, localization, and function of beta 1 integrins on cultured human epidermal keratinocytes using polyclonal and monoclonal antibodies against the beta 1, alpha 2, alpha 3, and alpha 5 integrin subunits. The beta 1 polypeptide, common to all class 1 integrins, was localized primarily in areas of cell-cell contacts of cultured keratinocytes, as were alpha 2 and alpha 3 polypeptides, suggesting a possible role in cell-cell adhesion for these integrin polypeptides. In contrast, the fibronectin receptor alpha 5 subunit showed no such accumulations in regions of cell-cell contact but was more diffusely distributed in the keratinocyte plasma membrane, consistent with the absence of fibronectin at cell-cell contact sites. Colonies of cultured keratinocytes could be dissociated by treatment with monoclonal antibody specific to the beta 1 polypeptide. Such dissociation of cell-cell contacts also occurred under conditions where the monoclonal antibody had no effect on cell-substrate adhesion. Therefore, beta 1 integrin-dependent cell-cell adhesion can be inhibited without affecting other cell-adhesive interactions. Antibody treatment of keratinocytes maintained in either low (0.15 mM) or high (1.2 mM) CaCl2 also resulted in the loss of organization of intracellular F-actin filaments and beta 1 integrins, even when the anti-beta 1 monoclonal antibody had no dissociating effect on keratinocyte colonies at the higher calcium concentration. Our results indicate that beta 1 integrins play roles in the maintenance of cell-cell contacts between keratinocytes and in the organization of intracellular microfilaments. They suggest that in epithelial cells integrins can function in cell-cell interactions as well as in cell-substrate adhesion.
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