Evidence map›Paper›PMID 16897048›Full record

ArticleDer Nervenarzt2006

[Oral treatment of vitamin B12 deficiency in subacute combined degeneration].

J Wellmer, K-U Sturm, W Herrmann, J Hoever, T Klockgether, M Linnebank

Abstract readCase ReportsEnglish Abstract
PubMed Publisher
In one paragraph

Article in Der Nervenarzt, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. [Pancytopenia and callosal nodules].Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi · 2018
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

J WellmerKlinik und Poliklinik für Neurologie, Universitätsklinikum Bonn. j.wellmer@gmx.de
K-U Sturm
W Herrmann
J Hoever
T Klockgether
M Linnebank
Klinik und Poliklinik für Neurologie · DEIhre-Radiologen · DEUniversitätsklinikum des Saarlandes · DEUniversity Hospital Bonn · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vitamin B12 deficiency due to malnutrition or malabsorption may lead to pernicious anemia and neurological disorders. Although randomized prospective studies have shown that pernicious anemia can be safely treated with oral vitamin B12 even in the absence of intrinsic factor, it is still common practice to treat patients with neurological symptoms with intramuscular cyancobalamin injections. We report the successful oral treatment of subacute combined degeneration of the spinal cord in a 24-year-old woman closely monitored clinically with MRI and plasma levels of vitamin B12, homocysteine, and methylmalonic acid. We suggest monitored oral substitution therapy as first-line therapy for neurological disorders related to vitamin B12 deficiency.

Indexed as

Administration, OralAdultAnemia, PerniciousAutoantibodiesDose-Response Relationship, DrugFemaleFolic AcidHomocysteineHumansIntrinsic FactorMagnetic Resonance ImagingMethylmalonic AcidNeurologic ExaminationSpinal CordSpinal Cord DiseasesVitamin B 12AutoantibodiesFolic AcidHomocysteineIntrinsic FactorMethylmalonic AcidVitamin B 12

Identifiers

PMID16897048
OpenAlexW2599178873

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.