Trial reportPsychopharmacology2006
The antisaccade task as an index of sustained goal activation in working memory: modulation by nicotine.
Trial report in Psychopharmacology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 39 citations in OpenAlex.
- Effects of risperidone, amisulpride and nicotine on eye movement control and their modulation by schizotypy.Psychopharmacology · 2013Trial
- Nicotine differentially modulates antisaccade performance in healthy male non-smoking volunteers stratified for low and high accuracy.Psychopharmacology · 2012Trial
- Effect of D-amphetamine on inhibition and motor planning as a function of baseline performance.Psychopharmacology · 2010Trial
- Positive effects of nicotine on cognition: the deployment of attention for prospective memory.Psychopharmacology · 2009Trial
- Nicotine promotes the utility of short-term memory during visual search in macaque monkeys.Psychopharmacology · 2022Article
- The computational pharmacology of oculomotion.Psychopharmacology · 2019Article
- Consortium on the Genetics of Schizophrenia (COGS) assessment of endophenotypes for schizophrenia: an introduction to this Special Issue of Schizophrenia Research.Schizophrenia research · 2015Review
- Cognition as a therapeutic target in late-life depression: potential for nicotinic therapeutics.Biochemical pharmacology · 2013Review
- Varenicline potentiates alcohol-induced negative subjective responses and offsets impaired eye movements.Alcoholism, clinical and experimental research · 2012Article
- Degree of dependence influences the effect of smoking on cognitive flexibility.Pharmacology, biochemistry, and behavior · 2011Article
- Is the relationship of prosaccade reaction times and antisaccade errors mediated by working memory?Experimental brain research · 2011Article
- 'Alternate-goal bias' in antisaccades and the influence of expectation.Experimental brain research · 2010Article
- The effects of task instructions on pro and antisaccade performance.Experimental brain research · 2009Article
- Nicotine withdrawal-induced deficits in trace fear conditioning in C57BL/6 mice--a role for high-affinity beta2 subunit-containing nicotinic acetylcholine receptors.The European journal of neuroscience · 2009Article
- Pharmacological treatment effects on eye movement control.Brain and cognition · 2008Review
- Nicotine effects on retrieval-induced forgetting are not attributable to changes in arousal.Psychopharmacology · 2008Article
- Non-cholinergic modulation of antisaccade performance: a modafinil-nicotine comparison.Psychopharmacology · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe antisaccade task provides a laboratory analogue of situations in which execution of the correct behavioural response requires the suppression of a more prepotent or habitual response. Errors (failures to inhibit a reflexive prosaccade towards a sudden onset target) are significantly increased in patients with damage to the dorsolateral prefrontal cortex and patients with schizophrenia. Recent models of antisaccade performance suggest that errors are more likely to occur when the intention to initiate an antisaccade is insufficiently activated within working memory. Nicotine has been shown to enhance specific working memory processes in healthy adults. MATERIALS AND
methodsWe explored the effect of nicotine on antisaccade performance in a large sample (N = 44) of young adult smokers. Minimally abstinent participants attended two test sessions and were asked to smoke one of their own cigarettes between baseline and retest during one session only. RESULTS AND
conclusionNicotine reduced antisaccade errors and correct antisaccade latencies if delivered before optimum performance levels are achieved, suggesting that nicotine supports the activation of intentions in working memory during task performance. The implications of this research for current theoretical accounts of antisaccade performance, and for interpreting the increased rate of antisaccade errors found in some psychiatric patient groups are discussed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.