ArticleVirchows Archiv : an international journal of pathology2006
The high frequency of EBV infection in pediatric Hodgkin lymphoma is related to the classical type in Bahia, Brazil.
Article in Virchows Archiv : an international journal of pathology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 38 citations in OpenAlex.
- Hodgkin Lymphoma in Children: A 16-year Experience at the Children's Welfare Teaching Hospital of Baghdad, Iraq.Mediterranean journal of hematology and infectious diseases · 2024Article
- Review
- Review
- Frequency of EBV associated classical Hodgkin lymphoma decreases over a 54-year period in a Brazilian population.Scientific reports · 2018Article
- A new hypothesis for the cancer mechanism.Cancer metastasis reviews · 2012Review
- Epidemiology of classical Hodgkin lymphoma and its association with Epstein Barr virus in Northern China.PloS one · 2011Article
- Epstein-Barr virus and Hodgkin's lymphoma in Cairo, Egypt.Journal of hematopathology · 2010Article
- Pediatric lymphomas in Brazil.Clinics (Sao Paulo, Brazil) · 2010Article
- Hodgkin lymphoma: an update on its biology with new insights into classification.Clinical lymphoma & myeloma · 2009Review
- Frequent expression of multiple myeloma 1/interferon regulatory factor 4 in Burkitt lymphoma.Human pathology · 2009Article
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8 authors at 4 institutions in 2 countries.
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Abstract
Pediatric Hodgkin lymphoma (HL) occurring in developing regions is different from HL in industrialized countries due to the higher frequency of association with Epstein-Barr virus (EBV) infection. This infection is related to classical HL (cHL) but is virtually absent in nodular lymphocyte predominant HL (nLPHL). We studied the phenotype and the expression of EBV gene products in 90 pediatric cases by immunohistochemistry and in situ hybridization. EBV-positive tumor cells were found exclusively in cHL. The infection occurred with high frequency in all cHL subtypes, but it predominated in the mixed cellularity and lymphocyte depletion subtypes. These results reinforce the hypothesis that EBV plays a major role in the etiology of pediatric cHL in developing areas. Curiously, the frequency of EBV infection in HL was identical to the previously described for Burkitt's lymphoma in the same pediatric population. As both lymphomas have a postulated precursor cell in the germinal center (GC), the pattern of latently EBV-infected GC cells previously described in Bahia may be related to the development of these lymphomas.
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