ArticleIntensive care medicine2006
Serum procalcitonin measurement contribution to the early diagnosis of candidemia in critically ill patients.
Article in Intensive care medicine, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 73 citations in OpenAlex.
- Procalcitonin levels in candidemia versus bacteremia: a systematic review.Critical care (London, England) · 2019Pooled it
- Machine learning model based on clinical and imaging features for predicting fungal infections in children with leukemia.BMC pediatrics · 2026Article
- Prognostic Utility of Delta-Procalcitonin and Modified Shock Index for Risk Stratification of Sepsis in Acute Care Settings.Journal of community hospital internal medicine perspectives · 2026Article
- The Diagnostic Accuracy of Procalcitonin and Its Combination with Other Biomarkers for Candidemia in Critically Ill Patients.Journal of clinical medicine · 2024Article
- Guidelines for the Use of Procalcitonin for Rational Use of Antibiotics.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2022Article
- The Impact of the FilmArray-Based Detection of Microbial Pathogens from Positive Blood Culture Vials on the Time to Optimal Antimicrobial Regimen in Intensive Care Units of the Helios University Clinic Wuppertal, Germany.Journal of clinical medicine · 2021Article
- Infection biomarkers in assisting the judgement of blood stream infection and patient prognosis: a retrospective study incorporating principal components analysis.Annals of translational medicine · 2020Article
- Early diagnostic value of serum procalcitonin levels for catheter-related blood stream infection in first-ever acute ischemic stroke patients.BMC neurology · 2020Article
- Clinical characteristics and predictors of mortality in patients with candidemia: a six-year retrospective study.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2018Article
- Increased presepsin levels are associated with the severity of fungal bloodstream infections.PloS one · 2018Article
- Usefulness of procalcitonin in differentiating Candida and bacterial blood stream infections in critically ill septic patients outside the intensive care unit.Internal and emergency medicine · 2017Article
- Combined use of serum (1,3)-β-D-glucan and procalcitonin for the early differential diagnosis between candidaemia and bacteraemia in intensive care units.Critical care (London, England) · 2017Article
- Procalcitonin for the diagnosis of invasive candidiasis: what is the evidence?Journal of intensive care · 2017Article
- Response of letter to the editor on Procalcitonin: a promising diagnostic marker for sepsis and antibiotic therapy.Journal of intensive care · 2017Article
- Bloodstream infections in internal medicine.Virulence · 2016Review
- Procalcitonin as a marker of Candida species detection by blood culture and polymerase chain reaction in septic patients.BMC anesthesiology · 2014Article
- Biomarkers for sepsis: a review with special attention to India.BioMed research international · 2014Review
- Observational
- [Invasive candidiasis in non-neutropenic adults : Guideline-based management in the intensive care unit].Der Anaesthesist · 2013Review
- A quick and low-cost PCR-based assay for Candida spp. identification in positive blood culture bottles.BMC infectious diseases · 2013Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCandidemia is a life-threatening infection in the ICU whose prognosis is highly dependent on the stage at which it is recognized. Procalcitonin (PCT) levels have been shown to accurately distinguish between bacteremia and noninfectious inflammatory states in critically ill patients with clinical signs of sepsis. Little is known about the accuracy of PCT for the diagnosis of candidemia in this setting.
settingA medical intensive care unit in a teaching hospital. PATIENTS AND
methodsReview of the medical records of every non-neutropenic patient with either bacteremia or candidemia and clinical sepsis in whom PCT dosage at the onset of infection was available between May 2004 and December 2005.
resultsFifty episodes of either bacteremia (n=35) or candidemia (n=15) were included. PCT levels were found to be markedly higher in patients with bacteremia than in those with candidemia. Moreover, a low PCT value was found to be an independent predictor of candidemia in the study population. According to the calculation of the area under the receiver operating characteristic curve, PCT was found to be accurate in distinguishing between candidemia and bacteremia (0.96 [0.03]). A PCT level of higher than 5.5 ng/ml yields a 100% negative predictive value and a 65.2% positive predictive value for candidemia-related sepsis.
conclusionA high PCT value in a critically ill non-neutropenic patient with clinical sepsis is unlikely in the setting of candidemia.
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