ArticleEuropean journal of clinical pharmacology2006
Prevalence and patterns of antidepressant drug use during pregnancy.
Article in European journal of clinical pharmacology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
73 citing papers in PubMed, 4 syntheses or guidelines pooled it, 175 citations in OpenAlex.
- Sertraline use in the first trimester and risk of congenital anomalies: a systemic review and meta-analysis of cohort studies.British journal of clinical pharmacology · 2017Pooled it
- Use of selective serotonin-reuptake inhibitors in the first trimester and risk of cardiovascular-related malformations: a meta-analysis of cohort studies.Scientific reports · 2017Pooled it
- The risk of major cardiac malformations associated with paroxetine use during the first trimester of pregnancy: a systematic review and meta-analysis.British journal of clinical pharmacology · 2016Pooled it
- Maternal use of antidepressant or anxiolytic medication during pregnancy and childhood neurodevelopmental outcomes: a systematic review.European child & adolescent psychiatry · 2014Pooled it
- Effects of bright light therapy for depression during pregnancy: a randomised, double-blind controlled trial.BMJ open · 2020Trial
- Bright light therapy in pregnant women with major depressive disorder: study protocol for a randomized, double-blind, controlled clinical trial.BMC psychiatry · 2016Trial
- Stop or go? Preventive cognitive therapy with guided tapering of antidepressants during pregnancy: study protocol of a pragmatic multicentre non-inferiority randomized controlled trial.BMC psychiatry · 2016Trial
- Effect of cytochrome P450 2D6 genotype on maternal paroxetine plasma concentrations during pregnancy.Clinical pharmacokinetics · 2009Trial
- Effect of the Gestational Fluoxetine Administration on Behavioral Tests and Hippocampal Structure in Male Offspring of Rats.International journal of molecular sciences · 2025Article
- Medication use from conception to the first antenatal appointment: agreement between maternal self-report to midwife and prescribing records in Northern Ireland in 2011-2016.International journal of population data science · 2025Article
- Sertraline, citalopram and paroxetine in lactation: passage into breastmilk and infant exposure.Frontiers in pharmacology · 2024Article
- Article
- Psychiatric disorders during pregnancy in asymptomatic and mildly symptomatic SARS-CoV-2 positive women: Prevalence and effect on outcome.Psychiatry research · 2023Article
- Should Antidepressants be Avoided in Pregnancy?Drug safety · 2023Review
- Prenatal Venlafaxine Exposure-Induced Neurocytoarchitectural and Neuroapoptotic Degeneration in Striatum and Hippocampus of Developing Fetal Brain, Manifesting Long-term Neurocognitive Impairments in Rat Offspring.Neurotoxicity research · 2022Article
- Allopregnanolone Concentrations in Breast Milk and Plasma from Healthy Volunteers Receiving Brexanolone Injection, With Population Pharmacokinetic Modeling of Potential Relative Infant Dose.Clinical pharmacokinetics · 2022Article
- Early-life exposure to selective serotonin reuptake inhibitors: Long-term effects on pain and affective comorbidities.The European journal of neuroscience · 2022Review
- Antidepressant Fill and Dose Trajectories in Pregnant Women with Depression and/or Anxiety: A Norwegian Registry Linkage Study.Clinical epidemiology · 2022Article
- Article
- Acceptance, experiences, and needs of hospitalized pregnant women toward an electronic mindfulness-based intervention: A pilot mixed-methods study.Frontiers in psychiatry · 2022Article
13 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe aim of this study was to determine the extent and patterns of antidepressant use before, during and after pregnancy in a large population in The Netherlands.
methodsHealth care records and prescription data from one of the largest Dutch health insurance companies were analysed. The study cohort consisted of 29,005 women who had live births in the period between January 2000 and July 2003. Antidepressant drug use during a specified period was defined as there being a record of a prescription during that period.
resultsDuring the first trimester of pregnancy 2% of all pregnant women of the study cohort were found to have taken antidepressants; in the second and third trimesters, this figure had dropped to 1.8% of all pregnancies. Antidepressant use before as well as during pregnancy was almost twofold higher in women over 35 years of age than in those under 35 years. Almost 60% of the women who used antidepressants before pregnancy stopped taking them in the first trimester, and a smaller number stopped thereafter. Of all women using antidepressants during pregnancy, one third started this medication during gestation. In the 3 months following delivery, the prevalence of antidepressant use was the same as before pregnancy (2.9%). There was no shift to benzodiazepines in the group of women who stopped taking antidepressants during pregnancy. Although paroxetine and fluoxetine were the most frequently used antidepressants among the study group, all modern antidepressants were used.
conclusionA considerable number of women are being exposed to antidepressants throughout pregnancy up until delivery. One consequence of this is that their newborns need special care and supervision during the first days of life. However, women who stop taking the medication may risk a relapse of their illness, and this may also have a negative effect on the child.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.