ArticleMolecular and cellular biochemistry2006
Age- and cell cycle-dependent changes in EPC-1/PEDF promoter activity in human diploid fibroblast-like (HDF) cells.
Article in Molecular and cellular biochemistry, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 14 citations in OpenAlex.
- The Various Roles of PEDF in Cancer.Cancers · 2024Review
- Targeting Transcription Factor YY1 for Cancer Treatment: Current Strategies and Future Directions.Cancers · 2023Review
- Polarized retinal pigment epithelium generates electrical signals that diminish with age and regulate retinal pathology.Journal of cellular and molecular medicine · 2018Article
- Pigment epithelium-derived factor: clinical significance in estrogen-dependent tissues and its potential in cancer therapy.Iranian journal of basic medical sciences · 2015Review
- Identification of molecules derived from human fibroblast feeder cells that support the proliferation of human embryonic stem cells.Cellular & molecular biology letters · 2011Article
- Polarized secretion of PEDF from human embryonic stem cell-derived RPE promotes retinal progenitor cell survival.Investigative ophthalmology & visual science · 2011Article
- Article
- Alterations in microRNA expression in stress-induced cellular senescence.Mechanisms of ageing and developmentArticle
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The changes in gene expression during senescence are very interesting. Early population doubling cDNA-1 (EPC-1, also known as pigment epithelial derived factor, PEDF) is one of the genes whose expression decreases dramatically during cellular aging. We examined whether or not EPC-1/PEDF promoter activity was affected by the cellular ageing using human diploid lung fibroblast cells in culture. Here we showed the promoter/enhancer region of EPC-1/PEDF existed at more than 1760 bp upstream from the transcriptional initiation site of the gene, and was regulated by both aging and cell cycle. These findings suggest that the expression of the EPC-1/PEDF gene is, at least in part, regulated transcriptionally in the cells. The analysis of the promoter region of the EPC-1/PEDF gene in this paper suggests the age- and cell cycle-dependent expression of specific transcriptional factor(s).
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Registered trials
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