ArticleEukaryotic cell2006
The Opi1p transcription factor affects expression of FLO11, mat formation, and invasive growth in Saccharomyces cerevisiae.
Article in Eukaryotic cell, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 34 citations in OpenAlex.
- Transcriptomic atlas throughout Coccidioides development reveals key phase-enriched transcripts of this important fungal pathogen.PLoS biology · 2025Article
- Transcriptomic atlas of the morphologic development of the fungal pathogenbioRxiv : the preprint server for biology · 2024Article
- Conserved signaling modules regulate filamentous growth in fungi: a model for eukaryotic cell differentiation.Genetics · 2024Review
- Ecological inducers of the yeast filamentous growth pathway reveal environment-dependent roles for pathway components.mSphere · 2023Article
- Opi1-mediated transcriptional modulation orchestrates genotoxic stress response in budding yeast.Genetics · 2023Article
- Influence of Different Aggregation States on Volatile Organic Compounds Released by DairyFoods (Basel, Switzerland) · 2022Article
- Gene by Environment Interactions reveal new regulatory aspects of signaling network plasticity.PLoS genetics · 2022Article
- Filamentation Regulatory Pathways Control Adhesion-Dependent Surface Responses in Yeast.Genetics · 2019Article
- Cell Wall Surface Properties ofFrontiers in microbiology · 2019Article
- Going with the Flo: The Role of Flo11-Dependent and Independent Interactions in Yeast Mat Formation.Journal of fungi (Basel, Switzerland) · 2018Review
- Candida albicans OPI1 regulates filamentous growth and virulence in vaginal infections, but not inositol biosynthesis.PloS one · 2015Article
- Article
- The genetic architecture of biofilm formation in a clinical isolate of Saccharomyces cerevisiae.Genetics · 2013Article
- Identification of a complex genetic network underlying Saccharomyces cerevisiae colony morphology.Molecular microbiology · 2012Article
- Regulation of mat responses by a differentiation MAPK pathway in Saccharomyces cerevisiae.PloS one · 2012Article
- The regulation of filamentous growth in yeast.Genetics · 2012Review
- Vacuolar protein sorting genes regulate mat formation in Saccharomyces cerevisiae by Flo11p-dependent and -independent mechanisms.Eukaryotic cell · 2011Article
- Multiple signals converge on a differentiation MAPK pathway.PLoS genetics · 2010Article
- The inositol regulon controls viability in Candida glabrata.Microbiology (Reading, England) · 2010Article
- The tRNA modification complex elongator regulates the Cdc42-dependent mitogen-activated protein kinase pathway that controls filamentous growth in yeast.Eukaryotic cell · 2009Article
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1 author at 1 institution in 1 country.
Funding
Abstract
Mat formation in the bakers' yeast Saccharomyces cerevisiae is a surface-associated phenomenon in which yeast cells spread over the surface of a low-density agar petri plate as a complex film. This spreading growth occurs by sliding motility and is dependent on the adhesion protein (adhesin) Flo11p. In order to identify molecular pathways that govern mat formation, whole-genome transcriptional profiling was used to compare cells growing as a mat to cells growing in a suspension culture (planktonic cells). This analysis revealed that S. cerevisiae upregulates a subset of genes in response to growth on a surface. These genes included the INO1 gene, which encodes the myo-inositol-1-phosphate synthase, which carries out the rate-limiting step in inositol biosynthesis. Further inquiry revealed that a transcription factor that controls INO1 expression, called Opi1p, participates in the regulation of mat formation. Opi1p appears to modulate mat formation by influencing the expression of FLO11. The opi1Delta mutant was found to exhibit reduced FLO11 levels. Consequently, the opi1Delta mutant perturbs the FLO11-dependent phenotype of invasive growth. The opi1Delta mutant's defects in mat formation and invasive growth are dependent on the transcriptional activator Ino2p. These results indicate that Opi1p affects mat formation and invasive growth by participating in the regulation of FLO11.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.