ArticleEukaryotic cell2006
Characterization and developmentally regulated localization of the mitochondrial carrier protein homologue MCP6 from Trypanosoma brucei.
Article in Eukaryotic cell, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 41 citations in OpenAlex.
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- Subcellular protein localisation ofWellcome open research · 2023Article
- Lipid and fatty acid metabolism in trypanosomatids.Microbial cell (Graz, Austria) · 2021Review
- Novel Cytoskeleton-Associated Proteins inMicroorganisms · 2021Article
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- A Protein Complex Map of Trypanosoma brucei.PLoS neglected tropical diseases · 2016Article
- RNA interference screen reveals a high proportion of mitochondrial proteins essential for correct cell cycle progress in Trypanosoma brucei.BMC genomics · 2015Article
- The ADP/ATP carrier and its relationship to oxidative phosphorylation in ancestral protist trypanosoma brucei.Eukaryotic cell · 2015Article
- Trypanosome MKT1 and the RNA-binding protein ZC3H11: interactions and potential roles in post-transcriptional regulatory networks.Nucleic acids research · 2014Article
- Proteins associated with SF3a60 in T. brucei.PloS one · 2014Article
- The trypanosome Pumilio domain protein PUF5.PloS one · 2013Article
- Proteins and lipids of glycosomal membranes from Leishmania tarentolae and Trypanosoma brucei.F1000Research · 2013Article
- Functional characterization of TbMCP5, a conserved and essential ADP/ATP carrier present in the mitochondrion of the human pathogen Trypanosoma brucei.The Journal of biological chemistry · 2012Article
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- Channel-forming activities in the glycosomal fraction from the bloodstream form of Trypanosoma brucei.PloS one · 2012Article
- Adenine nucleotide transporters in organelles: novel genes and functions.Cellular and molecular life sciences : CMLS · 2011Review
- Functional characterisation and drug target validation of a mitotic kinesin-13 in Trypanosoma brucei.PLoS pathogens · 2010Article
- The trypanosome Pumilio-domain protein PUF7 associates with a nuclear cyclophilin and is involved in ribosomal RNA maturation.FEBS letters · 2010Article
- The role of deadenylation in the degradation of unstable mRNAs in trypanosomes.Nucleic acids research · 2009Article
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Proteins of the mitochondrial carrier family (MCF) are located mainly in the inner mitochondrial membrane and mediate the transport of a large range of metabolic intermediates. The genome of Trypanosoma brucei harbors 29 genes encoding different MCF proteins. We describe here the characterization of MCP6, a novel T. brucei MCF protein. Sequence comparison and phylogenetic reconstruction revealed that MCP6 is closely related to different mitochondrial ADP/ATP and calcium-dependent solute carriers, including the ATP-Mg/Pi carrier of Homo sapiens. However, MCP6 lacks essential amino acids and sequence motifs conserved in these metabolite transporters, and functional reconstitution and transport assays with E. coli suggested that this protein indeed does not function as an ADP/ATP or ATP-Mg/Pi carrier. The subcellular localization of MCP6 is developmentally regulated: in bloodstream-form trypanosomes, the protein is predominantly glycosomal, whereas in the procyclic form, it is found mainly in the mitochondria. Depletion of MCP6 in procyclic trypanosomes resulted in growth inhibition, an increased cell size, aberrant numbers of nuclei and kinetoplasts, and abnormal kinetoplast morphology, suggesting that depletion of MCP6 inhibits division of the kinetoplast.
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