ArticleThe American journal of pathology1990
The neuroendocrine and neural profiles of neuroblastomas, ganglioneuroblastomas, and ganglioneuromas.
Article in The American journal of pathology, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 59 citations in OpenAlex.
- Nerve Density and Neuronal Biomarkers in Cancer.Cancers · 2022Review
- Expression of Microtubule-Associated Proteins in Relation to Prognosis and Efficacy of Immunotherapy in Non-Small Cell Lung Cancer.Frontiers in oncology · 2021Article
- Synaptic Vesicle Protein 2 and Vesicular Monoamine Transporter 1 and 2 Are Expressed in Neuroblastoma.Endocrine pathology · 2019Article
- Surgical Excision of an Adrenal Neuroblastoma in a Dog.Frontiers in veterinary science · 2019Article
- Favorable prognostic role of tropomodulins in neuroblastoma.Oncotarget · 2018Article
- Activated ALK collaborates with MYCN in neuroblastoma pathogenesis.Cancer cell · 2012Article
- Ganglioneuroblastoma of the posterior mediastinum: a case report.Journal of medical case reports · 2011Article
- Adrenal ganglioneuroma accompanying catecholamine-producing adrenocortical cells.Journal of endocrinological investigation · 2009Article
- Distinct morphological and immunohistochemical features and different growth rates among four human neuroblastomas heterotransplanted into nude mice.Medical molecular morphology · 2008Article
- Secretagogin, a novel neuroendocrine marker, has a distinct expression pattern from chromogranin A.Virchows Archiv : an international journal of pathology · 2006Article
- Primitive neuroectodermal tumors of the central nervous system.Brain pathology (Zurich, Switzerland) · 1997Review
- The granin protein family: markers for neuroendocrine cells and tools for the diagnosis of neuroendocrine tumors.Journal of endocrinological investigation · 1994Review
- Widespread distribution of tau in the astrocytic elements of glial tumors.Acta neuropathologica · 1993Article
- Prognostic importance of DNA flow cytometrical, histopathological and immunohistochemical parameters in neuroblastomas.Virchows Archiv. A, Pathological anatomy and histopathology · 1992Article
- Nerve growth factor receptor expression in peripheral and central neuroectodermal tumors, other pediatric brain tumors, and during development of the adrenal gland.The American journal of pathology · 1991Article
- Functioning and nonfunctioning adrenal medullary tumors.Endocrine pathology · 1991Review
- Routine histological compared with immunohistological examination of bone marrow trephine biopsy specimens in disseminated neuroblastoma.Journal of clinical pathology · 1991Article
- Neuroectodermal tumors of the peripheral and the central nervous system share neuroendocrine N-CAM-related antigens with small cell lung carcinomas.Acta neuropathologica · 1991Article
- Progesterone induction of tau phosphorylation during the differentiation of human embryonic stem cells into neuroectodermal rosettes.Journal of Alzheimer's disease reportsArticle
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
To establish the neuroendocrine and neural features of peripheral neuroblastic tumors, a prospectively collected group of 12 neuroblastomas (NB), 2 ganglioneuroblastomas (GNB), and 4 ganglioneuromas (GN) was probed with a panel of monoclonal antibodies (MAbs) to neuroendocrine and neural antigens. All tumors expressed the pan-neuroendocrine markers synaptophysin and chromogranin A. They also showed extensive expression of neuronal antigens, ie, of each of the neurofilament (NF) triplet proteins and of the microtubule-associated proteins (MAPs) MAP2 and tau-protein. However, only in the GNBs and GNs was the pattern of NF phosphoisoforms relatively mature. In the latter tumors glial fibrillary acidic protein (GFAP) and myelin basic protein (MBP) could be demonstrated as well, suggesting the presence of nonmyelinating and myelinating Schwann cells, respectively. The glial markers did not colocalize with the neural markers. On the basis of these data, it was concluded that all peripheral neuroblastic tumors manifest molecular characteristics of neuroendocrine cells and of neurons. The latter were most developed in GNBs and GNs, in which they were accompanied by Schwann cell differentiation in a separate population of cells. The above-outlined neuronal profile of peripheral neuroblastic tumors, including NBs, distinguishes this group of tumors from the much-less neuronally differentiated primitive neuroectodermal tumors of the central nervous system.
Indexed as
Identifiers
1689542PMC1877414W2192055577What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.