ArticleMolecular psychiatry2006
The analysis of 51 genes in DSM-IV combined type attention deficit hyperactivity disorder: association signals in DRD4, DAT1 and 16 other genes.
Article in Molecular psychiatry, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 221 papers, 10 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
221 citing papers in PubMed, 10 syntheses or guidelines pooled it, 15 citations in OpenAlex.
- A systematic review and meta-analysis examining the interrelationships between chemical and non-chemical stressors and inherent characteristics in children with ADHD.Environmental research · 2020Pooled it
- Association study and a systematic meta-analysis of the VNTR polymorphism in the 3'-UTR of dopamine transporter gene and attention-deficit hyperactivity disorder.Journal of neural transmission (Vienna, Austria : 1996) · 2019Pooled it
- Association of Serotonin Receptors with Attention Deficit Hyperactivity Disorder: A Systematic Review and Meta-analysis.Current medical science · 2018Pooled it
- Brain imaging genetics in ADHD and beyond - Mapping pathways from gene to disorder at different levels of complexity.Neuroscience and biobehavioral reviews · 2017Pooled it
- Pooled it
- Role of dopamine receptors in ADHD: a systematic meta-analysis.Molecular neurobiology · 2012Pooled it
- Electrophysiological markers of genetic risk for attention deficit hyperactivity disorder.Expert reviews in molecular medicine · 2011Pooled it
- Meta-analysis of genome-wide association studies of attention-deficit/hyperactivity disorder.Journal of the American Academy of Child and Adolescent Psychiatry · 2010Pooled it
- Candidate gene studies of ADHD: a meta-analytic review.Human genetics · 2009Pooled it
- Candidate genes and neuropsychological phenotypes in children with ADHD: review of association studies.Journal of psychiatry & neuroscience : JPN · 2009Pooled it
- DRD3 Gene and ADHD: A Pharmaco-Behavioural Genetic Study.Neuromolecular medicine · 2018Trial
- Further evidence that pediatric-onset bipolar disorder comorbid with ADHD represents a distinct subtype: results from a large controlled family study.Journal of psychiatric research · 2013Trial
- Independent oscillatory patterns determine performance fluctuations in children with attention deficit/hyperactivity disorder.Brain : a journal of neurology · 2011Trial
- A controlled family study of children with DSM-IV bipolar-I disorder and psychiatric co-morbidity.Psychological medicine · 2010Trial
- Polymorphisms in dopamine transporter (SLC6A3) are associated with stimulant effects of D-amphetamine: an exploratory pharmacogenetic study using healthy volunteers.Behavior genetics · 2010Trial
- Further evidence of association between amphetamine response and SLC6A2 gene variants.Psychopharmacology · 2009Trial
- From childhood to adulthood: an attempt to model long-term outcomes of ADHD using machine learning.European child & adolescent psychiatry · 2026Article
- Stimulant medication and symptom interrelations in children, adolescents and adults with attention-deficit/hyperactivity disorder.European child & adolescent psychiatry · 2025Article
- Serotonin dysfunction in ADHD.Journal of neurodevelopmental disorders · 2025Review
- Transcriptomic Dysregulation in Animal Models of Attention-Deficit Hyperactivity Disorder and Nicotine Dependence Suggests Shared Neural Mechanisms.Brain and behavior · 2025Article
161 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issuedAneey, R [corrected to Anney, R]
Authors and funding
63 authors at 15 institutions in 9 countries.
Funding
Abstract
Attention deficit hyperactivity disorder (ADHD) is a common neurodevelopmental disorder, starting in early childhood and persisting into adulthood in the majority of cases. Family and twin studies have demonstrated the importance of genetic factors and candidate gene association studies have identified several loci that exert small but significant effects on ADHD. To provide further clarification of reported associations and identify novel associated genes, we examined 1,038 single-nucleotide polymorphisms (SNPs) spanning 51 candidate genes involved in the regulation of neurotransmitter pathways, particularly dopamine, norepinephrine and serotonin pathways, in addition to circadian rhythm genes. Analysis used within family tests of association in a sample of 776 DSM-IV ADHD combined type cases ascertained for the International Multi-centre ADHD Gene project. We found nominal significance with one or more SNPs in 18 genes, including the two most replicated findings in the literature: DRD4 and DAT1. Gene-wide tests, adjusted for the number of SNPs analysed in each gene, identified associations with TPH2, ARRB2, SYP, DAT1, ADRB2, HES1, MAOA and PNMT. Further studies will be needed to confirm or refute the observed associations and their generalisability to other samples.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.