ArticleMolecular psychiatry2006
Genetic and clinical analysis of a large Dutch Gilles de la Tourette family.
Article in Molecular psychiatry, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The genetics of trichotillomania and excoriation disorder: A systematic review.Comprehensive psychiatry · 2024Pooled it
- Developmental control of noradrenergic system by SLITRK1 and its implications in the pathophysiology of neuropsychiatric disorders.Frontiers in molecular neuroscience · 2022Review
- Lack of Association ofNeuropsychiatric disease and treatment · 2022Article
- Article
- Tourette Syndrome Risk Genes Regulate Mitochondrial Dynamics, Structure, and Function.Frontiers in psychiatry · 2020Article
- Targeted Re-Sequencing Approach of Candidate Genes Implicates Rare Potentially Functional Variants in Tourette Syndrome Etiology.Frontiers in neuroscience · 2016Article
- Functional Evaluations of Genes Disrupted in Patients with Tourette's Disorder.Frontiers in psychiatry · 2016Review
- Tourette Syndrome: Bridging the Gap between Genetics and Biology.Molecular neuropsychiatry · 2015Article
- Abnormal neuronal activity in Tourette syndrome and its modulation using deep brain stimulation.Journal of neurophysiology · 2015Review
- Porcine SLITRK1: Molecular cloning and characterization.FEBS open bio · 2014Article
- Balance within the Neurexin Trans-Synaptic Connexus Stabilizes Behavioral Control.Frontiers in human neuroscience · 2014Review
- Genetic susceptibility and neurotransmitters in Tourette syndrome.International review of neurobiology · 2013Review
- Article
- The leucine-rich repeat superfamily of synaptic adhesion molecules: LRRTMs and Slitrks.Molecules and cells · 2012Review
- Pathogenetic model for Tourette syndrome delineates overlap with related neurodevelopmental disorders including Autism.Translational psychiatry · 2012Review
- The genetics of Tourette syndrome.Nature reviews. Neurology · 2012Review
- The genetics of Tourette disorder.Current opinion in genetics & development · 2011Review
- Slitrks as emerging candidate genes involved in neuropsychiatric disorders.Trends in neurosciences · 2011Review
- Tourette disorder spectrum maps to chromosome 14q31.1 in an Italian kindred.Neurogenetics · 2010Article
- MicroRNAs in psychiatric and neurodevelopmental disorders.Brain research · 2010Review
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Gilles de la Tourette syndrome is a complex neuropsychiatric disorder, which becomes evident in childhood between the ages of 2 and 15 years. Tourette syndrome is defined by the occurrence of a large range and variable number of unwanted repetitive simple or complex motor and vocal tics that start in childhood and follow a waxing and waning course. A major gene for this syndrome has not yet been identified, probably owing to both genetic and phenotypic heterogeneity of this disease. This article describes the clinical evaluation of patients and family members in a large Dutch Gilles de la Tourette Syndrome pedigree and the decisions encountered with respect to phenotyping. The importance of an accurate definition of the Tourette phenotype is discussed, which is highly important for reliable genetic linkage and association studies. Subsequent linkage analysis resulted in three linkage peaks on different chromosomes 3q, 9q, and 13q. Multipoint analysis resulted in a single linkage peak with logarithm of odds score 2.55 with marker D3S1311 on chromosome 3q.
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