ArticleNucleic acids research2006
Sequence elements critical for efficient RNA editing of a tobacco chloroplast transcript in vivo and in vitro.
Article in Nucleic acids research, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 48 citations in OpenAlex.
- Beyond a PPR-RNA recognition code: Many aspects matter for the multi-targeting properties of RNA editing factor PPR56.PLoS genetics · 2023Article
- U-to-C RNA editing by synthetic PPR-DYW proteins in bacteria and human culture cells.Communications biology · 2022Article
- An RNA recognition motif-containing protein is required for plastid RNA editing in Arabidopsis and maize.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- RIP1, a member of an Arabidopsis protein family, interacts with the protein RARE1 and broadly affects RNA editing.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- When you can't trust the DNA: RNA editing changes transcript sequences.Cellular and molecular life sciences : CMLS · 2011Review
- Testing for selection on synonymous sites in plant mitochondrial DNA: the role of codon bias and RNA editing.Journal of molecular evolution · 2010Article
- A study of new Arabidopsis chloroplast RNA editing mutants reveals general features of editing factors and their target sites.The Plant cell · 2009Article
- CURE-Chloroplast: a chloroplast C-to-U RNA editing predictor for seed plants.BMC bioinformatics · 2009Article
- Post-transcriptional control of chloroplast gene expression.Gene regulation and systems biology · 2009Article
- High conservation of a 5' element required for RNA editing of a C target in chloroplast psbE transcripts.Journal of molecular evolution · 2008Article
- Cross-competition in editing of chloroplast RNA transcripts in vitro implicates sharing of trans-factors between different C targets.The Journal of biological chemistry · 2008Article
- Article
- Faithful editing of a tomato-specific mRNA editing site in transgenic tobacco chloroplasts.RNA (New York, N.Y.) · 2008Article
- Two RNA editing sites with cis-acting elements of moderate sequence identity are recognized by an identical site-recognition protein in tobacco chloroplasts.Nucleic acids research · 2008Article
- Identification of a sequence motif critical for editing of a tobacco chloroplast transcript.RNA (New York, N.Y.) · 2007Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
In tobacco chloroplast transcripts 34 nt are efficiently edited to U. No common consensus region is present around all editing sites; however, sites can be grouped in clusters that share short common sequences. Transgene transcripts carrying either the wild-type -31/+22 or -31/+60 sequence near NTrpoB C473, an editing site within tobacco rpoB transcripts, or three different mutated sequences, were all highly edited in vivo. Endogenous transcripts of rpoB, psbL and rps14, all of which contain common sequences S1, S2 and S3 5' to NTrpoB C473, NTpsbL C2 and NTrps14 C80, were less edited in transgenic plants that over-express transcripts from NTrpoB C473 transgenes. Extent of reduction of endogenous editing differed between transgenic lines expressing mutated -31/+22 regions, depending on the abundance of the transgene transcripts. The -20/-5 sequence contains critical 5' sequence elements. Synthetic RNA templates with alterations within this 5' region were less efficiently edited in vitro than wild-type templates, by either tobacco or maize chloroplast extracts. The tobacco chloroplast extract supports both RNA editing and processing of 3' transcript termini. We conclude that within the -20/-5 region, sequences common to editing sites in the transcripts of rpoB, psbL and rps14 are critical for efficient NTrpoB C473 editing.
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