ArticleCellscience2006
The Genetic Basis of Type 2 Diabetes.
Article in Cellscience, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
55 citing papers in PubMed, 1 synthesis or guideline pooled it, 155 citations in OpenAlex.
- Joint analysis of individual participants' data from 17 studies on the association of the IL6 variant -174G>C with circulating glucose levels, interleukin-6 levels, and body mass index.Annals of medicine · 2009Pooled it
- Assessment of the Therapeutic Potential of Persimmon Leaf Extract on Prediabetic Subjects.Molecules and cells · 2017Trial
- Severity of Dental Caries and Saliva Properties in Diabetes Mellitus.Dentistry journal · 2025Article
- The Association Between Health Belief Model Components and Self-Care Practices Among Black/African American Men with Type 2 Diabetes.International journal of environmental research and public health · 2025Article
- The impact of sociodemographic determinants and diabetes type-2 on oral health outcomes: An analytical cross-sectional study.Clinical and experimental dental research · 2024Article
- Partners in diabetes epidemic: A global perspective.World journal of diabetes · 2023Review
- One-Year Mean A1c of > 7% is Associated with Poor Bone Microarchitecture and Strength in Men with Type 2 Diabetes Mellitus.Calcified tissue international · 2022Article
- Dairy Lactic Acid Bacteria and Their Potential Function in Dietetics: The Food-Gut-Health Axis.Foods (Basel, Switzerland) · 2021Review
- Mechanisms Underlying the Comorbidity of Schizophrenia and Type 2 Diabetes Mellitus.The international journal of neuropsychopharmacology · 2021Review
- Genome-scale mechanistic modeling of signaling pathways made easy: A bioconductor/cytoscape/web server framework for the analysis of omic data.Computational and structural biotechnology journal · 2021Article
- The impact of low mineral content water on cardiac function in diabetic rats: focus on oxidative stress.Molecular and cellular biochemistry · 2020Article
- Review
- Article
- The Play of Genes and Non-genetic Factors on Type 2 Diabetes.Frontiers in public health · 2019Review
- Two Novel Candidate Genes for Insulin Secretion Identified by Comparative Genomics of Multiple Backcross Mouse Populations.Genetics · 2018Article
- Epidemiological Investigation of Type 2 Diabetes and Alzheimer's Disease in a Pakistani Population.International journal of environmental research and public health · 2018Article
- Possible association between ABCC8 C49620T polymorphism and type 2 diabetes in a Nigerian population.BMC medical genetics · 2018Article
- Efficacy of Alpha Glucosidase Inhibitor from Marine Actinobacterium in the Control of Postprandial Hyperglycaemia in Streptozotocin (STZ) Induced Diabetic Male Albino Wister Rats.Iranian journal of pharmaceutical research : IJPR · 2018Article
- Type 2 diabetes and obesity induce similar transcriptional reprogramming in human myocytes.Genome medicine · 2017Article
- Association of Vitamin D Deficiency and Degree of Coronary Artery Disease in Cardiac Patients with Type 2 Diabetes.Journal of diabetes research · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Type 2 Diabetes results from a complex physiologic process that includes the pancreatic beta cells, peripheral glucose uptake in muscle, the secretion of multiple cytokines and hormone-like molecules from adipocytes, hepatic glucose production, and likely the central nervous system. Consistent with the complex web of physiologic defects, the emerging picture of the genetics will involve a large number of risk susceptibility genes, each individually with relatively small effect (odds ratios below 1.2 in most cases). The challenge for the future will include cataloging and confirming the genetic risk factors, and understanding how these risk factors interact with each other and with the known environmental and lifestyle risk factors that increase the propensity to type 2 diabetes.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.