ReviewOncogene2006
Mitochondrial factors with dual roles in death and survival.
Review in Oncogene, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 69 citations in OpenAlex.
- Tipping-point transition from transient to persistent inflammation in pancreatic islets.NPJ systems biology and applications · 2024Article
- Whi2 signals low leucine availability to halt yeast growth and cell death.FEMS yeast research · 2018Review
- 6'-Hydroxy Justicidin B Triggers a Critical Imbalance in CaFrontiers in pharmacology · 2018Article
- Article
- F1FO ATPase vesicle preparation and technique for performing patch clamp recordings of submitochondrial vesicle membranes.Journal of visualized experiments : JoVE · 2013Article
- Multiple functions of BCL-2 family proteins.Cold Spring Harbor perspectives in biology · 2013Review
- Bid protects the mouse hematopoietic system following hydroxyurea-induced replicative stress.Cell death and differentiation · 2012Article
- Article
- Neuroprotection in metabolism-based therapy.Epilepsy research · 2012Review
- Cytosolic Bax: does it require binding proteins to keep its pro-apoptotic activity in check?The Journal of biological chemistry · 2012Article
- BID binds to replication protein A and stimulates ATR function following replicative stress.Molecular and cellular biology · 2011Article
- Proapoptotic Bid mediates the Atr-directed DNA damage response to replicative stress.Cell death and differentiation · 2011Article
- Hepatitis C virus protects human B lymphocytes from Fas-mediated apoptosis via E2-CD81 engagement.PloS one · 2011Article
- Identification and characterization of genes involved in leishmania pathogenesis: the potential for drug target selection.Molecular biology international · 2011Article
- High expression of BCL-2 predicts favorable outcome in non-small cell lung cancer patients with non squamous histology.BMC cancer · 2010Article
- Purification of mitochondria from yeast cells.Journal of visualized experiments : JoVE · 2009Article
- Mitochondrial DNA content and lung cancer risk in Xuan Wei, China.Lung cancer (Amsterdam, Netherlands) · 2009Article
- BAD: undertaker by night, candyman by day.Oncogene · 2008Review
- Mitochondrial death pathways in yeast and mammalian cells.Biochimica et biophysica acta · 2008Review
- Apigenin-induced prostate cancer cell death is initiated by reactive oxygen species and p53 activation.Free radical biology & medicine · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 4 institutions in 1 country.
Funding
Abstract
At least in mammals, we have some understanding of how caspases facilitate mitochondria-mediated cell death, but the biochemical mechanisms by which other factors promote or inhibit programmed cell death are not understood. Moreover, most of these factors are only studied after treating cells with a death stimulus. A growing body of new evidence suggests that cell death regulators also have 'day jobs' in healthy cells. Even caspases, mitochondrial fission proteins and pro-death Bcl-2 family proteins appear to have normal cellular functions that promote cell survival. Here, we review some of the supporting evidence and stretch beyond the evidence to seek an understanding of the remaining questions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.