Evidence map›Paper›PMID 16891485›Full record

ArticleJournal of clinical microbiology2006

Measles virus-specific antibody levels in individuals in Argentina who received a one-dose vaccine.

Marcelo H Argüelles, Mariana L Orellana, Alejandro A Castello, Guillermo A Villegas, Matilde Masini, Alejandra L Belizan, Silvia González Ayala, Osmar D Vera, Graciela Glikmann

Open access · greenAbstract readComparative Study
In one paragraph

Article in Journal of clinical microbiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.4field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Synthesis of Evidence to Characterize National Measles and Rubella Exposure and Immunization Histories.Risk analysis : an official publication of the Society for Risk Analysis · 2016
    Article
  7. Article
  8. Article
  9. Article
  10. Expression and purification of Z protein from Junín virus.Journal of biomedicine & biotechnology · 2010
    Article
  11. Prevalence of Maternal Measles Antibody and Its Associated Factors among Infants in Coastal Karnataka, India.Indian journal of community medicine : official publication of Indian Association of Preventive & Social Medicine
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Marcelo H ArgüellesLaboratorio de Inmunología y Virología, Departamento de Ciencia y Tecnología, Universidad Nacional de Quilmes, Roque Sáenz Peña 352, Bernal (B1876BXD), Buenos Aires, Argentina.
Mariana L Orellana
Alejandro A Castello
Guillermo A Villegas
Matilde Masini
Alejandra L Belizan
Silvia González Ayala
Osmar D Vera
Graciela Glikmann
National University of Quilmes · ARAgencia Nacional de Promoción de la Investigación, el Desarrollo Tecnológico y la Innovación · ARHospital de Niños Superiora Sor María Ludovica · AR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In spite of active measles virus (MV) vaccination strategies, reemergence continues to occur, impairing global eradication programs. The immune status against measles was evaluated in 350 vaccinated healthy Argentine children and teenagers who received a single dose of the MV Schwarz strain Lirugen vaccine (Aventis Pasteur). Sera were assessed for immunoglobulin G (IgG) antibodies by a commercial enzyme immunoassay (EIA) (Enzygnost; Behring), an in-house EIA, and neutralization EIA. Results obtained with these methods showed a marked decline in IgG level with increasing age. At 1 to 4 years of age, 84% of children had IgG antibodies above 200 mIU/ml, conventionally accepted as protective levels, whereas only 32% of older children and teenagers had antibody levels exceeding 200 mIU/ml. Moreover, the MV IgG content in the teenage group was significantly lower than the IgG antibody level of the group of younger children (P < 0.0001). In contrast, screening for IgG antibody levels to inactivated tetanus vaccine showed that, on average, 80% of this population was fully protected and that this high level of protection remained through the teenage years. This study suggests that within this population a considerable proportion of individuals had low measles antibody levels that may be insufficient to protect against reinfections or clinical disease.

Indexed as

AdolescentAge FactorsAntibodies, BacterialAntibodies, ViralArgentinaChildChild, PreschoolFemaleHumansImmunoenzyme TechniquesImmunoglobulin GInfantMaleMeaslesMeasles VaccineMeasles virusAntibodies, BacterialAntibodies, ViralImmunoglobulin GMeasles VaccineTetanus Toxoid

Identifiers

PMID16891485
PMCPMC1594608
OpenAlexW2111395432

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.