ArticleProceedings of the National Academy of Sciences of the United States of America2006
Early evolution of animal cell signaling and adhesion genes.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 116 papers.
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Who cites it
116 citing papers in PubMed, 329 citations in OpenAlex.
- Article
- Nematode extracellular protein interactome expands connections between signaling pathways.Cell genomics · 2026Article
- Article
- Planar cell polarity coordination in a cnidarian embryo provides clues to animal body axis evolution.eLife · 2025Article
- The Buds of Oscarella lobularis (Porifera, Homoscleromorpha): A New Convenient Model for Sponge Cell and Evolutionary Developmental Biology.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2024Article
- Nematode Extracellular Protein Interactome Expands Connections between Signaling Pathways.bioRxiv : the preprint server for biology · 2024Article
- The origin and evolution of Wnt signalling.Nature reviews. Genetics · 2024Review
- The compact genome of the sponge Oopsacas minuta (Hexactinellida) is lacking key metazoan core genes.BMC biology · 2023Article
- Dome1-JAK-STAT signaling between parasite and host integrates vector immunity and development.Science (New York, N.Y.) · 2023Article
- Structure and evolution of neuronal wiring receptors and ligands.Developmental dynamics : an official publication of the American Association of Anatomists · 2023Review
- Exploring genome gene content and morphological analysis to test recalcitrant nodes in the animal phylogeny.PloS one · 2023Article
- Varied solutions to multicellularity: The biophysical and evolutionary consequences of diverse intercellular bonds.Biophysics reviews · 2022Review
- Evolutionary plasticity in the requirement for force exerted by ligand endocytosis to activate C. elegans Notch proteins.Current biology : CB · 2022Article
- Functions of the FGF signalling pathway in cephalochordates provide insight into the evolution of the prechordal plate.Development (Cambridge, England) · 2022Article
- Neural is Fundamental: Neural Stemness as the Ground State of Cell Tumorigenicity and Differentiation Potential.Stem cell reviews and reports · 2022Review
- Cell polarity signalling at the birth of multicellularity: What can we learn from the first animals.Frontiers in cell and developmental biology · 2022Review
- An evolutionary and physiological perspective on cell-substrate adhesion machinery for cell migration.Frontiers in cell and developmental biology · 2022Review
- Evolution of mechanisms controlling epithelial morphogenesis across animals: new insights from dissociation-reaggregation experiments in the sponge Oscarella lobularis.BMC ecology and evolution · 2021Article
- Maximum likelihood reconstruction of ancestral networks by integer linear programming.Bioinformatics (Oxford, England) · 2021Article
- The origin of animals: an ancestral reconstruction of the unicellular-to-multicellular transition.Open biology · 2021Review
56 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In stark contrast to the rapid morphological radiation of eumetazoans during the Cambrian explosion, the simple body plan of sponges (Phylum Porifera) emerged from the Cambrian relatively unchanged. Although the genetic and developmental underpinnings of these disparate evolutionary outcomes are unknown, comparisons between modern sponges and eumetazoans promise to reveal the extent to which critical genetic factors were present in their common ancestors. Two particularly interesting classes of genes in this respect are those involved in cell signaling and adhesion. These genes help guide development and morphogenesis in modern eumetazoans, but the timing and sequence of their origins is unknown. Here, we demonstrate that the sponge Oscarella carmela, one of the earliest branching animals, expresses core components of the Wnt, transforming growth factor beta, receptor tyrosine kinase, Notch, Hedgehog, and Jak/Stat signaling pathways. Furthermore, we identify sponge homologs of nearly every major eumetazoan cell-adhesion gene family, including those that encode cell-surface receptors, cytoplasmic linkers, and extracellular-matrix proteins. From these data, we infer that key signaling and adhesion genes were in place early in animal evolution, before the divergence of sponge and eumetazoan lineages.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.