ArticleProceedings of the National Academy of Sciences of the United States of America2006
Basonuclins 1 and 2, whose genes share a common origin, are proteins with widely different properties and functions.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 53 citations in OpenAlex.
- BNC2 in Development and Disease: Regulatory Mechanisms and Translational Implications.Molecules (Basel, Switzerland) · 2026Review
- BNC2 as a putative transcriptional coordinator linking energy state to neural circuits.iScience · 2026Review
- Modelling human lower urinary tract malformations in zebrafish.Molecular and cellular pediatrics · 2023Review
- Article
- Integration of a single-step genome-wide association study with a multi-tissue transcriptome analysis provides novel insights into the genetic basis of wool and weight traits in sheep.Genetics, selection, evolution : GSE · 2021Article
- Expanding congenital abnormalities of the kidney and urinary tract (CAKUT) genetics: basonuclin 2 (BNC2) and lower urinary tract obstruction.Annals of translational medicine · 2019Article
- Rare Variants in BNC2 Are Implicated in Autosomal-Dominant Congenital Lower Urinary-Tract Obstruction.American journal of human genetics · 2019Article
- Signatures of Archaic Adaptive Introgression in Present-Day Human Populations.Molecular biology and evolution · 2017Article
- Human basonuclin 2 up-regulates a cascade set of interferon-stimulated genes with anti-cancerous properties in a lung cancer model.Cancer cell international · 2017Article
- BNC2 is a putative tumor suppressor gene in high-grade serous ovarian carcinoma and impacts cell survival after oxidative stress.Cell death & disease · 2016Article
- Identification of Susceptibility Loci for Cutaneous Squamous Cell Carcinoma.The Journal of investigative dermatology · 2016Article
- Decreased Expression of BNC1 and BNC2 Is Associated with Genetic or Epigenetic Regulation in Hepatocellular Carcinoma.International journal of molecular sciences · 2016Article
- Interactions with iridophores and the tissue environment required for patterning melanophores and xanthophores during zebrafish adult pigment stripe formation.PLoS genetics · 2013Article
- Human balanced translocation and mouse gene inactivation implicate Basonuclin 2 in distal urethral development.European journal of human genetics : EJHG · 2011Article
- Genetic variation at 9p22.2 and ovarian cancer risk for BRCA1 and BRCA2 mutation carriers.Journal of the National Cancer Institute · 2011Article
- Article
- Web-based, participant-driven studies yield novel genetic associations for common traits.PLoS genetics · 2010Article
- A survey of well conserved families of C2H2 zinc-finger genes in Daphnia.BMC genomics · 2010Article
- Integrative analysis of the human cis-antisense gene pairs, miRNAs and their transcription regulation patterns.Nucleic acids research · 2010Article
- Chromosomal abnormalities and novel disease-related regions in progression from Barrett's esophagus to esophageal adenocarcinoma.International journal of cancer · 2009Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Basonuclin (bn) 1 possesses three separated pairs of zinc fingers and a nuclear localization signal. It is largely confined to the basal cells of stratified squamous epithelia and to reproductive germ cells. bn1 can shuttle between the nucleus and the cytoplasm, and its location is correlated with the proliferative potential of the cell. The recently discovered bn2 also possesses three separated pairs of zinc fingers and a nuclear localization signal. Conservation of the zinc fingers and the nuclear localization signal by bn1 and bn2 indicates a common origin. However, in contrast to bn1, bn2 is found in virtually every cell type and is confined to the nucleus. Bn2 but not bn1 colocalizes with SC35 in nuclear speckles and, therefore, is likely to have a function in nuclear processing of mRNA.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.