ArticleProceedings of the National Academy of Sciences of the United States of America1990
Murine beta 1,4-galactosyltransferase: both the amounts and structure of the mRNA are regulated during spermatogenesis.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 102 citations in OpenAlex.
- Stage-specific changes in GDNF expression by rat Sertoli cells: a possible regulator of the replication and differentiation of stem spermatogonia.Biology of reproduction · 2011Article
- The expression patterns of beta1,4 galactosyltransferase I and V mRNAs, and Galbeta1-4GlcNAc group in rat gastrocnemius muscles post sciatic nerve injury.Glycoconjugate journal · 2008Article
- Stage-specific gene expression is a fundamental characteristic of rat spermatogenic cells and Sertoli cells.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Diversity in tissue expression, substrate binding, and SCF complex formation for a lectin family of ubiquitin ligases.The Journal of biological chemistry · 2008Article
- Article
- TIP27: a novel repressor of the nuclear orphan receptor TAK1/TR4.Nucleic acids research · 2004Article
- Knockout of mouse beta 1,4-galactosyltransferase-1 gene results in a dramatic shift of outer chain moieties of N-glycans from type 2 to type 1 chains in hepatic membrane and plasma glycoproteins.The Biochemical journal · 2001Article
- Regulation of expression of the human beta-1,2-N-acetylglucosaminyltransferase II gene (MGAT2) by Ets transcription factors.The Biochemical journal · 2000Article
- A novel 14-base-pair regulatory element is essential for in vivo expression of murine beta4-galactosyltransferase-I in late pachytene spermatocytes and round spermatids.Molecular and cellular biology · 1999Article
- Comparison of lectin-binding patterns between young adults and older rat glycoproteins in the brain.Glycoconjugate journal · 1998Article
- Differentiation -dependent expression of human beta-galactoside alpha 2,6-sialyltransferase mRNA in colon carcinoma CaCo-2 cells.Glycoconjugate journal · 1996Article
- Odorant receptors and desensitization proteins colocalize in mammalian sperm.Molecular medicine (Cambridge, Mass.) · 1995Article
- Heterogeneity in the 5' untranslated region of mouse cytochrome cT mRNAs leads to altered translational status of the mRNAs.Nucleic acids research · 1994Article
- Overexpressing sperm surface beta 1,4-galactosyltransferase in transgenic mice affects multiple aspects of sperm-egg interactions.The Journal of cell biology · 1994Article
- DNA methyltransferase is developmentally expressed in replicating and non-replicating male germ cells.Nucleic acids research · 1992Article
- Pachytene spermatocyte protein(s) stimulate Sertoli cells grown in bicameral chambers: dose-dependent secretion of ceruloplasmin, sulfated glycoprotein-1, sulfated glycoprotein-2, and transferrin.In vitro cellular & developmental biology : journal of the Tissue Culture Association · 1991Article
- Article
- Molecular structure of Tcp-10 genes from the t complex responder locus.Mammalian genome : official journal of the International Mammalian Genome Society · 1991Article
- Molecular cloning and expression of cDNA encoding the enzyme that controls conversion of high-mannose to hybrid and complex N-glycans: UDP-N-acetylglucosamine: alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I.Proceedings of the National Academy of Sciences of the United States of America · 1991Article
- List of cloned mouse genes with unique expression patterns during spermatogenesis.Mammalian genome : official journal of the International Mammalian Genome Society · 1991Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Previously we have shown that the gene encoding murine beta 1,4-galactosyltransferase (beta 1,4-GT; UDPgalactose:N-acetyl-D-glucosaminyl-glycopeptide 4-beta-D-galactosyltransferase, EC 2.4.1.38) is unusual in that it specifies two sets of mRNAs of about 3.9 and 4.1 kilobases (kb). Translation of the 3.9- and 4.1-kb mRNAs results in the predicted synthesis of two related membrane-bound forms of the protein of 386 amino acids (short form) and 399 amino acids (long form), respectively. In this study we have examined the expression of beta 1,4-GT during murine spermatogenesis. Spermatogonia contain a 4.1-kb transcript that is comparable in size to the beta 1,4-GT mRNA identified in somatic cells. During differentiation from spermatogonia (2n) to pachytene spermatocytes (4n), the amount of beta 1,4-GT mRNA is reduced to barely detectable levels. Continued differentiation to round spermatids (n) is coincident with a renewed production of beta 1,4-GT mRNA to levels comparable with those detected in spermatogonia. However, the characteristic 4.1-kb mRNA detected in spermatogonia is replaced by two truncated transcripts of 2.9 and 3.1 kb. By S1 nuclease analysis, the 2.9- and 3.1-kb transcripts were shown to encode the same open reading frame as the 4.1-kb transcript found in somatic cells. The shorter round spermatid transcripts arise as a consequence of the use of alternative poly(A) signals. Lastly, we show that, in direct contrast to all somatic tissues and cell lines examined to date, male germ cells synthesize only the long form of the beta 1,4-GT polypeptide.
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