ArticleJournal of controlled release : official journal of the Controlled Release Society2006
Manipulation of hydrogel assembly and growth factor delivery via the use of peptide-polysaccharide interactions.
Article in Journal of controlled release : official journal of the Controlled Release Society, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
39 citing papers in PubMed, 124 citations in OpenAlex.
- Hydrogel-Based Nitric Oxide Delivery Systems for Enhanced Wound Healing.Gels (Basel, Switzerland) · 2025Review
- Functionalized Collagen/Poly(ethylene glycol) Diacrylate Interpenetrating Network Hydrogel Enhances Beta Pancreatic Cell Sustenance.Gels (Basel, Switzerland) · 2023Article
- Synthesis and Hydrogelation of Star-Shaped Graft Copolypetides with Asymmetric Topology.Gels (Basel, Switzerland) · 2022Article
- Growth factor loading on aliphatic polyester scaffolds.RSC advances · 2021Review
- Evaluation of oat β-glucan-marine collagen peptide mixed gel and its application as the fat replacer in the sausage products.PloS one · 2020Article
- Controlling the Release of Small, Bioactive Proteins via Dual Mechanisms with Therapeutic Potential.Advanced healthcare materials · 2017Article
- Synthetic hydrogels mimicking basement membrane matrices to promote cell-matrix interactions.Matrix biology : journal of the International Society for Matrix Biology · 2017Review
- Approaches for building bioactive elements into synthetic scaffolds for bone tissue engineering.Journal of materials chemistry. B · 2016Article
- The effect of glycosaminoglycan content on polyethylenimine-based gene delivery within three-dimensional collagen-GAG scaffolds.Biomaterials science · 2015Article
- Design of growth factor sequestering biomaterials.Chemical communications (Cambridge, England) · 2014Review
- Heparin-functionalized polymeric biomaterials in tissue engineering and drug delivery applications.Acta biomaterialia · 2014Review
- Incorporation of heparin into biomaterials.Acta biomaterialia · 2014Review
- Specific VEGF sequestering to biomaterials: influence of serum stability.Acta biomaterialia · 2013Article
- The use of bioinspired alterations in the glycosaminoglycan content of collagen-GAG scaffolds to regulate cell activity.Biomaterials · 2013Article
- Resilin-based Materials for Biomedical Applications.ACS macro letters · 2013Article
- Hydrogels in Healthcare: From Static to Dynamic Material Microenvironments.Acta materialia · 2013Article
- Resilin-Based Hybrid Hydrogels for Cardiovascular Tissue Engineering.Macromolecules · 2013Article
- HelixSoft matter · 2012Article
- Growth factor delivery: how surface interactions modulate release in vitro and in vivo.Advanced drug delivery reviews · 2012Review
- Design properties of hydrogel tissue-engineering scaffolds.Expert review of medical devices · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The design of materials in which assembly, mechanical response, and biological properties are controlled by protein-polysaccharide interactions could provide materials that mimic the biological environment and find use in the delivery of growth factors. In the investigations reported here, a heparin-binding, coiled-coil peptide, PF4 ZIP, was employed to mediate the assembly of heparinized polymers. The heparin-binding affinity of this peptide was compared with that of other heparin-binding peptides (HBP) via heparin-sepharose chromatography and surface plasmon resonance (SPR) experiments. Results from these experiments indicate that PF4 ZIP demonstrates a higher heparin-binding affinity and heparin association rate when compared to the heparin-binding domains of antithrombin III (ATIII) and heparin-interacting protein (HIP). Viscoelastic hydrogels were formed upon the association of PF4 ZIP-functionalized star poly(ethylene glycol) (PEG-PF4 ZIP) with low-molecular-weight heparin-functionalized star PEG (PEG-LMWH). The viscoelastic properties of the hydrogels can be altered via variations in the ratio of LMWH to PF4 ZIP. bFGF release from these gels have also been investigated. Comparison of the bFGF release profiles with the hydrogel erosion profiles indicates that bFGF delivery from this class of hydrogels is mainly an erosion-controlled process and the rates of bFGF release can be modulated via choice of HBP or via variations in the mechanical properties of the hydrogels. Manipulation of hydrogel physical properties and erosion profiles will provide novel materials for controlled growth factor delivery and other biomedical applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.